Anticonvulsant; protects mice and rats against generalized tonic-clonic seizures induced by electroshock. Thought to act via inhibition of sodium channel activity.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 252.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||7.93 mL||39.64 mL||79.28 mL|
|2.5 mM||1.59 mL||7.93 mL||15.86 mL|
|5 mM||0.79 mL||3.96 mL||7.93 mL|
|25 mM||0.16 mL||0.79 mL||1.59 mL|
References are publications that support the biological activity of the product.
Schmutz et al (1994) Oxcarbazepine: preclinical anticonvulsant profile and putative mechanism of action. Epilepsia 35 S47 PMID: 8039471
Ambrosio et al (2002) Mechanism of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem.Res. 27 121 PMID: 11926264
Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83 PMID: 18717705
If you know of a relevant reference for Oxcarbazepine, please let us know.
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Keywords: Oxcarbazepine, Oxcarbazepine supplier, antiepileptics, anticonvulsants, anticonvulsives, sodium, channels, voltage-gated, Na+, voltage-dependent, inhibitors, inhibits, NaV, Voltage-gated, Sodium, Channels, 3864, Tocris Bioscience
Citations for Oxcarbazepine
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.