Anticonvulsant; protects mice and rats against generalized tonic-clonic seizures induced by electroshock. Thought to act via inhibition of sodium channel activity.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 252.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.96 mL||19.82 mL||39.64 mL|
|5 mM||0.79 mL||3.96 mL||7.93 mL|
|10 mM||0.4 mL||1.98 mL||3.96 mL|
|50 mM||0.08 mL||0.4 mL||0.79 mL|
References are publications that support the products' biological activity.
Schmutz et al (1994) Oxcarbazepine: preclinical anticonvulsant profile and putative mechanism of action. Epilepsia 35 S47 PMID: 8039471
Ambrosio et al (2002) Mechanism of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem.Res. 27 121 PMID: 11926264
Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83 PMID: 18717705
If you know of a relevant reference for Oxcarbazepine, please let us know.
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Keywords: Oxcarbazepine, supplier, antiepileptics, anticonvulsants, anticonvulsives, sodium, channels, voltage-gated, Na+, voltage-dependent, inhibitors, inhibits, NaV, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience
Citations for Oxcarbazepine
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