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Description: Anticonvulsant; inhibits Na+ channel activity
Chemical Name: 10,11-Dihydro-10-oxo-5H-dibenzo(Z)[b,f]azepine-5-carboxamide
Purity: ≥98% (HPLC)
Reviews (1)

Biological Activity for Oxcarbazepine

Oxcarbazepine is an anticonvulsant; protects mice and rats against generalized tonic-clonic seizures induced by electroshock. Thought to act via inhibition of sodium channel activity.

Technical Data for Oxcarbazepine

M. Wt 252.27
Formula C15H12N2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 28721-07-5
PubChem ID 34312
Smiles NC(N(C(C=CC=C3)=C3C2)C1=CC=CC=C1C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Oxcarbazepine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 12.61 50

Preparing Stock Solutions for Oxcarbazepine

The following data is based on the product molecular weight 252.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.93 mL 39.64 mL 79.28 mL
2.5 mM 1.59 mL 7.93 mL 15.86 mL
5 mM 0.79 mL 3.96 mL 7.93 mL
25 mM 0.16 mL 0.79 mL 1.59 mL

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Product Datasheets for Oxcarbazepine

References for Oxcarbazepine

References are publications that support the biological activity of the product.

Schmutz et al (1994) Oxcarbazepine: preclinical anticonvulsant profile and putative mechanism of action. Epilepsia 35 S47 PMID: 8039471

Ambrosio et al (2002) Mechanism of action of carbamaz. and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem.Res. 27 121 PMID: 11926264

Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83 PMID: 18717705

If you know of a relevant reference for Oxcarbazepine, please let us know.

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Keywords: Oxcarbazepine, Oxcarbazepine supplier, antiepileptics, anticonvulsants, anticonvulsives, sodium, channels, voltage-gated, Na+, voltage-dependent, inhibitors, inhibits, NaV, Voltage-gated, Sodium, Channels, 3864, Tocris Bioscience

Citations for Oxcarbazepine

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Currently there are no citations for Oxcarbazepine. Do you know of a great paper that uses Oxcarbazepine from Tocris? Please let us know.

Reviews for Oxcarbazepine

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Suppression of seizure-like events.
By Luca Zangrandi on 08/13/2021
Assay Type: In Vivo
Species: Mouse

Systemic in-vivo administration

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