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Submit ReviewOxcarbazepine
Description: Anticonvulsant; inhibits Na+ channel activity
Chemical Name: 10,11-Dihydro-10-oxo-5H-dibenzo(Z)[b,f]azepine-5-carboxamide
Purity: ≥98% (HPLC)
Biological Activity
Anticonvulsant; protects mice and rats against generalized tonic-clonic seizures induced by electroshock. Thought to act via inhibition of sodium channel activity.
Technical Data
| M. Wt | 252.27 |
| Formula | C15H12N2O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 28721-07-5 |
| PubChem ID | 34312 |
| InChI Key | CTRLABGOLIVAIY-UHFFFAOYSA-N |
| Smiles | NC(N(C(C=CC=C3)=C3C2)C1=CC=CC=C1C2=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.61 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 252.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.93 mL | 39.64 mL | 79.28 mL |
| 2.5 mM | 1.59 mL | 7.93 mL | 15.86 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.93 mL |
| 25 mM | 0.16 mL | 0.79 mL | 1.59 mL |
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References
References are publications that support the biological activity of the product.
Schmutz et al (1994) Oxcarbazepine: preclinical anticonvulsant profile and putative mechanism of action. Epilepsia 35 S47 PMID: 8039471
Ambrosio et al (2002) Mechanism of action of carbamaz. and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem.Res. 27 121 PMID: 11926264
Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83 PMID: 18717705
If you know of a relevant reference for Oxcarbazepine, please let us know.
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Keywords: Oxcarbazepine, Oxcarbazepine supplier, antiepileptics, anticonvulsants, anticonvulsives, sodium, channels, voltage-gated, Na+, voltage-dependent, inhibitors, inhibits, NaV, Voltage-gated, Sodium, Channels, 3864, Tocris Bioscience
Citations for Oxcarbazepine
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