Oxcarbazepine

Pricing Availability Delivery Time Qty
Cat.No. 3864 - Oxcarbazepine | C15H12N2O2 | CAS No. 28721-07-5
Description: Anticonvulsant; inhibits Na+ channel activity
Chemical Name: 10,11-Dihydro-10-oxo-5H-dibenzo(Z)[b,f]azepine-5-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Anticonvulsant; protects mice and rats against generalized tonic-clonic seizures induced by electroshock. Thought to act via inhibition of sodium channel activity.

Technical Data

M. Wt 252.27
Formula C15H12N2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 28721-07-5
PubChem ID 34312
InChI Key CTRLABGOLIVAIY-UHFFFAOYSA-N
Smiles NC(N(C(C=CC=C3)=C3C2)C1=CC=CC=C1C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.61 50

Preparing Stock Solutions

The following data is based on the product molecular weight 252.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.96 mL 19.82 mL 39.64 mL
5 mM 0.79 mL 3.96 mL 7.93 mL
10 mM 0.4 mL 1.98 mL 3.96 mL
50 mM 0.08 mL 0.4 mL 0.79 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Schmutz et al (1994) Oxcarbazepine: preclinical anticonvulsant profile and putative mechanism of action. Epilepsia 35 S47 PMID: 8039471

Ambrosio et al (2002) Mechanism of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem.Res. 27 121 PMID: 11926264

Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83 PMID: 18717705


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Citations for Oxcarbazepine

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Pathways for Oxcarbazepine

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