Veratridine

Pricing Availability Delivery Time Qty
Cat.No. 2918 - Veratridine | C36H51NO11 | CAS No. 71-62-5
Description: Voltage-gated Na+ channel opener
Chemical Name: 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.

Technical Data

M. Wt 673.79
Formula C36H51NO11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 71-62-5
PubChem ID 6280
InChI Key FVECELJHCSPHKY-YFUMOZOISA-N
Smiles O=C(C8=CC=C(OC)C(OC)=C8)O[C@H]1CC[C@@]2(C)[C@@]3([H])[C@@](O)1O[C@@]42[C@@]([C@@](C[C@H](O)[C@@]6(O)[C@]([H])5CN7[C@](CC[C@H](C)C7)([H])[C@@](O)6C)(O)[C@@]5(O)C4)([H])CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.69 50

Preparing Stock Solutions

The following data is based on the product molecular weight 673.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.48 mL 7.42 mL 14.84 mL
5 mM 0.3 mL 1.48 mL 2.97 mL
10 mM 0.15 mL 0.74 mL 1.48 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

McKinney et al (1986) Purification, solubility and pKa of veratridine. Anal.Biochem. 153 33 PMID: 3963380

Maroto et al (1994) Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine. Eur.J.Pharmacol. 270 331 PMID: 7805782

Fekete et al (2009) Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy. J.Neurochem. 111 745 PMID: 19719824


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Keywords: Veratridine, supplier, Sodium, channel, opener, neutoxin, Na+, Na, voltage-gated, ion, channels, neurotoxins, Voltage-gated, Sodium, Channels, Tocris Bioscience

2 Citations for Veratridine

Citations are publications that use Tocris products. Selected citations for Veratridine include:

Battefeld et al (2016) Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Biol Psychiatry 7 11298 PMID: 27161034

Malmersjö et al (2013) Neural progenitors organize in small-world networks to promote cell proliferation. Nat Commun 110 E1524 PMID: 23576737


Do you know of a great paper that uses Veratridine from Tocris? If so please let us know.

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