Veratridine

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Cat.No. 2918 - Veratridine | C36H51NO11 | CAS No. 71-62-5
Description: Voltage-gated Na+ channel opener
Chemical Name: 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews (1)
Literature

Biological Activity

Voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.

Technical Data

M. Wt 673.79
Formula C36H51NO11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 71-62-5
PubChem ID 6280
InChI Key FVECELJHCSPHKY-YFUMOZOISA-N
Smiles O=C(C8=CC=C(OC)C(OC)=C8)O[C@H]1CC[C@@]2(C)[C@@]3([H])[C@@](O)1O[C@@]42[C@@]([C@@](C[C@H](O)[C@@]6(O)[C@]([H])5CN7[C@](CC[C@H](C)C7)([H])[C@@](O)6C)(O)[C@@]5(O)C4)([H])CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.69 50

Preparing Stock Solutions

The following data is based on the product molecular weight 673.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.97 mL 14.84 mL 29.68 mL
2.5 mM 0.59 mL 2.97 mL 5.94 mL
5 mM 0.3 mL 1.48 mL 2.97 mL
25 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

McKinney et al (1986) Purification, solubility and pKa of veratridine. Anal.Biochem. 153 33 PMID: 3963380

Maroto et al (1994) Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine. Eur.J.Pharmacol. 270 331 PMID: 7805782

Fekete et al (2009) Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy. J.Neurochem. 111 745 PMID: 19719824


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Keywords: Veratridine, Veratridine supplier, Sodium, channel, opener, neutoxin, Na+, Na, voltage-gated, ion, channels, neurotoxins, Voltage-gated, Channels, 2918, Tocris Bioscience

4 Citations for Veratridine

Citations are publications that use Tocris products. Selected citations for Veratridine include:

Jones et al (2014) Human macrophage SCN5A activates an innate immune signaling pathway for antiviral host defense. J Biol Chem 289 35326 PMID: 25368329

Battefeld et al (2016) Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Biol Psychiatry 7 11298 PMID: 27161034

Bedut et al (2016) High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes. Am J Physiol Heart Circ Physiol 311 H44 PMID: 27199128

Malmersjö et al (2013) Neural progenitors organize in small-world networks to promote cell proliferation. Nat Commun 110 E1524 PMID: 23576737


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Reviews for Veratridine

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Increases intracellular Na+ and tissue swelling
By Anonymous on 05/02/2018
Assay Type: Ex Vivo
Species: Rat

Verstridine is a voltage-gated sodium channel agonist. It increases intracellular Na+ concentration and also induces cellular and tissue swelling. We used at 50 microM to rat brain slices.


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