Voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 673.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.48 mL||7.42 mL||14.84 mL|
|5 mM||0.3 mL||1.48 mL||2.97 mL|
|10 mM||0.15 mL||0.74 mL||1.48 mL|
|50 mM||0.03 mL||0.15 mL||0.3 mL|
References are publications that support the biological activity of the product.
McKinney et al (1986) Purification, solubility and pKa of veratridine. Anal.Biochem. 153 33 PMID: 3963380
Maroto et al (1994) Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine. Eur.J.Pharmacol. 270 331 PMID: 7805782
Fekete et al (2009) Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy. J.Neurochem. 111 745 PMID: 19719824
If you know of a relevant reference for Veratridine, please let us know.
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Keywords: Veratridine, Veratridine supplier, Sodium, channel, opener, neutoxin, Na+, Na, voltage-gated, ion, channels, neurotoxins, Voltage-gated, Channels, 2918, Tocris Bioscience
4 Citations for Veratridine
Citations are publications that use Tocris products. Selected citations for Veratridine include:
Battefeld et al (2016) Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Biol Psychiatry 7 11298 PMID: 27161034
Malmersjö et al (2013) Neural progenitors organize in small-world networks to promote cell proliferation. Nat Commun 110 E1524 PMID: 23576737
Bedut et al (2016) High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes. Am J Physiol Heart Circ Physiol 311 H44 PMID: 27199128
Jones et al (2014) Human macrophage SCN5A activates an innate immune signaling pathway for antiviral host defense. J Biol Chem 289 35326 PMID: 25368329
Do you know of a great paper that uses Veratridine from Tocris? Please let us know.
Reviews for Veratridine
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Verstridine is a voltage-gated sodium channel agonist. It increases intracellular Na+ concentration and also induces cellular and tissue swelling. We used at 50 microM to rat brain slices.
Literature in this Area
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