Pricing Availability   Qty
Description: Voltage-gated Na+ channel opener
Chemical Name: 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
Purity: ≥98% (HPLC)
Citations (6)
Reviews (2)
Literature (5)

Biological Activity for Veratridine

Veratridine is a voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.

Technical Data for Veratridine

M. Wt 673.79
Formula C36H51NO11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 71-62-5
PubChem ID 6280
Smiles O=C(C8=CC=C(OC)C(OC)=C8)O[C@H]1CC[C@@]2(C)[C@@]3([H])[C@@](O)1O[C@@]42[C@@]([C@@](C[C@H](O)[C@@]6(O)[C@]([H])5CN7[C@](CC[C@H](C)C7)([H])[C@@](O)6C)(O)[C@@]5(O)C4)([H])CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Veratridine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.69 50

Preparing Stock Solutions for Veratridine

The following data is based on the product molecular weight 673.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.97 mL 14.84 mL 29.68 mL
2.5 mM 0.59 mL 2.97 mL 5.94 mL
5 mM 0.3 mL 1.48 mL 2.97 mL
25 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Veratridine

Certificate of Analysis / Product Datasheet
Select another batch:

References for Veratridine

References are publications that support the biological activity of the product.

McKinney et al (1986) Purification, solubility and pKa of veratridine. Anal.Biochem. 153 33 PMID: 3963380

Maroto et al (1994) Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine. Eur.J.Pharmacol. 270 331 PMID: 7805782

Fekete et al (2009) Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy. J.Neurochem. 111 745 PMID: 19719824

If you know of a relevant reference for Veratridine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Voltage-gated Sodium (NaV) Channel Activators

Keywords: Veratridine, Veratridine supplier, Sodium, channel, opener, neutoxin, Na+, Na, voltage-gated, ion, channels, neurotoxins, Voltage-gated, Channels, 2918, Tocris Bioscience

6 Citations for Veratridine

Citations are publications that use Tocris products. Selected citations for Veratridine include:

Malmersjö et al (2013) Neural progenitors organize in small-world networks to promote cell proliferation. Nat Commun 110 E1524 PMID: 23576737

McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196

Agarwal et al (2017) Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93 587 PMID: 28132831

Battefeld et al (2016) Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Biol Psychiatry 7 11298 PMID: 27161034

Do you know of a great paper that uses Veratridine from Tocris? Please let us know.

Reviews for Veratridine

Average Rating: 5 (Based on 2 Reviews.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used Veratridine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Voltage sensitive sodium channel opening.
By Anonymous on 11/19/2018
Assay Type: Ex Vivo
Species: Mouse

Can be used to activate and open voltage sensitive sodium channels in neurons. Elicits rapid reaction when applied directly to tissue.

Increases intracellular Na+ and tissue swelling.
By Anonymous on 05/02/2018
Assay Type: Ex Vivo
Species: Rat

Verstridine is a voltage-gated sodium channel agonist. It increases intracellular Na+ concentration and also induces cellular and tissue swelling. We used at 50 microM to rat brain slices.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Ion Channel Product Listing

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Epilepsy Poster

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.