A 887826

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Cat.No. 4249 - A 887826 | C26H29ClN4O3 | CAS No. 1266212-81-0
Description: Potent voltage-dependent NaV1.8 channel blocker
Chemical Name: 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.

Compound Libraries

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Technical Data

M. Wt 480.99
Formula C26H29ClN4O3
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 1266212-81-0
PubChem ID 46919335
InChI Key JPJGFWKHSMUKFO-UHFFFAOYSA-N
Smiles ClC1=C(OCCCC)C=CC(C2=CN=CC(C(NCC3=CC=CN=C3N4CCOCC4)=O)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.05 50

Preparing Stock Solutions

The following data is based on the product molecular weight 480.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.16 mL 20.79 mL 41.58 mL
2.5 mM 0.83 mL 4.16 mL 8.32 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
25 mM 0.08 mL 0.42 mL 0.83 mL

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References

References are publications that support the biological activity of the product.

Zhang et al (2010) A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Neuropharmacology 59 201 PMID: 20566409


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Keywords: A 887826, A 887826 supplier, A887826, sodium, channel, blocker, blocks, NaV1.8, voltage-dependent, ion, channels, antiallodynic, Voltage-gated, Sodium, Channels, 4249, Tocris Bioscience

1 Citation for A 887826

Citations are publications that use Tocris products. Selected citations for A 887826 include:

Cho et al (2013) Injury-induced HDAC5 nuclear export is essential for axon regeneration. Nat Chem Biol 155 894 PMID: 24209626


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