Sipatrigine

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Cat.No. 4044 - Sipatrigine | C15H16Cl3N5 | CAS No. 130800-90-7
Description: NaV blocker; neuroprotective
Alternative Names: 619C89
Chemical Name: 2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Blocker of voltage-dependent sodium channels (NaV). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca2+ channels. Analog of lamotrigine (Cat. No. 1611).

Compound Libraries

Sipatrigine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 372.68
Formula C15H16Cl3N5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 130800-90-7
PubChem ID 60803
InChI Key PDOCBJADCWMDGL-UHFFFAOYSA-N
Smiles ClC1=CC(Cl)=C(Cl)C(C2=C(N)N=C(N3CCN(C)CC3)N=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.27 100
ethanol 9.32 25

Preparing Stock Solutions

The following data is based on the product molecular weight 372.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.42 mL 26.83 mL
5 mM 0.54 mL 2.68 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Leach et al (1993) BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 24 1063 PMID: 8100654

Graham et al (1994) Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J.Pharmacol.Exp.Ther. 269 854 PMID: 7910213

Stefani et al (1998) On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89. Br.J.Pharmacol. 125 1058 PMID: 9846645


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Keywords: Sipatrigine, supplier, nav, voltage-dependent, sodium, Na+, channels, blockers, neuroprotective, 619C89, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience

Citations for Sipatrigine

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Pathways for Sipatrigine

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