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Sipatrigine

Cat. No. 4044 Submit a Review Datasheet / COA / SDS
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Description: NaV blocker; neuroprotective
Alternative Names: 619C89
Chemical Name: 2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine
Purity: ≥99% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Sipatrigine

Sipatrigine is a blocker of voltage-dependent sodium channels (NaV). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca2+ channels. Analog of lamotrigine (Cat. No. 1611).

Technical Data for Sipatrigine

M. Wt 372.68
Formula C15H16Cl3N5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 130800-90-7
PubChem ID 60803
InChI Key PDOCBJADCWMDGL-UHFFFAOYSA-N
Smiles ClC1=CC(Cl)=C(Cl)C(C2=C(N)N=C(N3CCN(C)CC3)N=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sipatrigine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.27 100
ethanol 9.32 25

Preparing Stock Solutions for Sipatrigine

The following data is based on the product molecular weight 372.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.42 mL 26.83 mL
5 mM 0.54 mL 2.68 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References for Sipatrigine

References are publications that support the biological activity of the product.

Leach et al (1993) BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 24 1063 PMID: 8100654

Graham et al (1994) Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J.Pharmacol.Exp.Ther. 269 854 PMID: 7910213

Stefani et al (1998) On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89. Br.J.Pharmacol. 125 1058 PMID: 9846645

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Citations for Sipatrigine

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