Tetrodotoxin citrate

Pricing Availability Delivery Time Qty
Cat.No. 1069 - Tetrodotoxin citrate | C11H17N3O8 | CAS No. 18660-81-6
Description: Na+ channel blocker; citrate salt of tetrodotoxin (Cat. No. 1078)
Alternative Names: TTx citrate
Chemical Name: Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol citrate
Datasheet
Citations (35)
Reviews
Literature

Biological Activity

Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.

Technical Data

M. Wt 319.27
Formula C11H17N3O8
Storage Desiccate at -20°C
CAS Number 18660-81-6
PubChem ID 16759596
InChI Key CFMYXEVWODSLAX-CKYAAQHSSA-N
Smiles OC1(CO)[C@H](O4)C(O)[C@@]2([C@@H]([C@@H](O)N3)C1O[C@](O)4[C@H]2O)NC3=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 319.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gleitz et al (1996) The protective action of tetrodotoxin and (±)-kavain on anaerobic glycolysis, ATP content and intracellular Na+ and Ca2+ of anoxic brain vesicles. Neuropharmacology 35 1743 PMID: 9076753

Kao (1972) Pharmacology of tetrodotoxin and saxitoxin. Fed.Proc. 31 1117 PMID: 5032475

Kao (1986) Structure-activity relations of tetrodotoxin, saxitoxin, and analogues. Ann.N.Y.Acad.Sci. 479 52 PMID: 2434008

Merck Index 12 9382 PMID:


If you know of a relevant reference for Tetrodotoxin citrate, please let us know.

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Keywords: Tetrodotoxin citrate, supplier, Citrate, salt, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, TTx, citrate, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience

35 Citations for Tetrodotoxin citrate

Citations are publications that use Tocris products. Selected citations for Tetrodotoxin citrate include:

Thomsen et al (2016) Fixed single-cell transcriptomic characterization of human radial glial diversity. Proc Natl Acad Sci U S A 13 87 PMID: 26524239

Di Castro et al (2016) The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area Scientific Reports 6 34633 PMID: 27721466

Cichon and Gan (2015) Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity. Nature 520 180 PMID: 25822789

Dieck et al (2015) Direct visualization of newly synthesized target proteins in situ. Nat Methods 12 411 PMID: 25775042

Ouwenga and Dougherty (2015) Fmrp targets or not: long, highly brain-expressed genes tend to be implicated in autism and brain disorders. Mol Autism 6 16 PMID: 25789151

Brown and Wonnacott (2015) Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors. Gastroenterology 40 2047 PMID: 24728867

Slowik and Henderson (2015) Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference. J Neurosci 1848 1545 PMID: 25838126

Lee and Tepper (2007) A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons. J Neurosci 27 6531 PMID: 17567814

Han et al (2007) Dopaminergic modulation of spinal neuronal excitability. J Neurophysiol 27 13192 PMID: 18045913

Kato et al (2007) New transmembrane AMPA receptor regulatory protein isoform, γ-7, differentially regulates AMPA receptors. J Comp Physiol A Neuroethol Sens Neural Behav Phys 27 4969 PMID: 17475805

Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607 PMID: 16432510

Liu et al (2015) Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output. J Neurophysiol 35 5680 PMID: 25855181

Tseng et al (2015) Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. Front Cell Neurosci 112 1214 PMID: 25552561

Angelantonio et al (2015) Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R. PLoS One 9 409 PMID: 26528137

Jonas et al (2015) Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata. Neurochem Res 10 e0139107 PMID: 26407014

Halff et al (2014) A novel mechanism for nicotinic potentiation of glutamatergic synapses. J Neurosci 34 2051 PMID: 24501347

Austgen et al (2011) Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract. Mol Brain 106 1822 PMID: 21734104

Schicho et al (2006) Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. J Neurosci 131 1542 PMID: 17101327

Evans et al (2013) Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons. Neuron 80 973 PMID: 24267653

Montgomery et al (2013) Mis-expression of the BK K(+) channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behavior. Am J Physiol Cell Physiol 304 C299 PMID: 23174562

Ren et al (2013) Direct retino-raphe projection alters serotonergic tone and affective behavior. Neuropsychopharmacology 38 1163 PMID: 23370156

Bloodgood et al (2013) The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature 503 121 PMID: 24201284

Mameza et al (2013) SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region. Biochim Biophys Acta 288 26697 PMID: 23897824

Reutsky-Gefen et al (2013) Holographic optogenetic stimulation of patterned neuronal activity for vision restoration. Nat Methods 4 1509 PMID: 23443537

Tozzi et al (2012) A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. PLoS One 7 e38312 PMID: 22715379

Jurgens et al (2012) Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus. PLoS One 7 e45717 PMID: 23029198

Janssen et al (2012) Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons. J Neurosci 32 13889 PMID: 23035098

Austgen et al (2012) 5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii. PLoS One 108 2292 PMID: 22855775

Watmuff et al (2012) In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation. J Neurosci 7 e31999 PMID: 22384125

Dagostin et al (2012) Increased bursting glutamatergic neurotransmission in an auditory forebrain area of the zebra finch (Taenopygia guttata) induced by auditory stimulation. J Biol Chem 198 705 PMID: 22752655

Specht et al (2011) Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C. EMBO J 30 3842 PMID: 21829170

Stacpoole et al (2011) Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Nat Protoc 6 1229 PMID: 21799491

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176

Calloe et al (2011) Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A. Can J Physiol Pharmacol 89 723 PMID: 21895525

Vornanen et al (2011) Tetrodotoxin sensitivity of the vertebrate cardiac Na+ current. Mar Drugs 9 2409 PMID: 22163193


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