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Submit ReviewFlecainide acetate
Description: Cardiac Na+ channel blocker. Antiarrhythmic
Chemical Name: N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate
Purity: ≥99% (HPLC)
Biological Activity for Flecainide acetate
Flecainide acetate is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.
Compound Libraries for Flecainide acetate
Flecainide acetate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Flecainide acetate
| M. Wt | 474.4 |
| Formula | C17H20F6N2O3.C2H4O2 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 54143-56-5 |
| PubChem ID | 41022 |
| InChI Key | RKXNZRPQSOPPRN-UHFFFAOYSA-N |
| Smiles | CC(O)=O.FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(=C1)C(=O)NCC1CCCCN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Flecainide acetate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.86 | 25 | |
| DMSO | 47.44 | 100 |
Preparing Stock Solutions for Flecainide acetate
The following data is based on the product molecular weight 474.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.11 mL | 10.54 mL | 21.08 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.11 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets for Flecainide acetate
References for Flecainide acetate
References are publications that support the biological activity of the product.
Banitt et al (1977) Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides. J.Med.Chem. 20 821 PMID: 874956
Rouet and Ducouret (1994) Use-and concentration-dependent effects of fleca. in guinea pig right ventricular muscle. J.Cardiovasc.Pharmacol. 24 177 PMID: 7526048
Singh et al (1984) The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. Ann.N.Y.Acad.Sci. 17 251 PMID: 6395762
If you know of a relevant reference for Flecainide acetate, please let us know.
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Keywords: Flecainide acetate, Flecainide acetate supplier, Cardiac, Na+, channel, blockers, Antiarrhythmic, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 1470, Tocris Bioscience
1 Citation for Flecainide acetate
Citations are publications that use Tocris products. Selected citations for Flecainide acetate include:
Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Neurosci 9 e96691 PMID: 24798465
Do you know of a great paper that uses Flecainide acetate from Tocris? Please let us know.
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