Flecainide acetate

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Cat.No. 1470 - Flecainide acetate | C17H20F6N2O3.C2H4O2 | CAS No. 54143-56-5
Description: Cardiac Na+ channel blocker. Antiarrhythmic
Chemical Name: N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.

Compound Libraries

Flecainide acetate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 474.4
Formula C17H20F6N2O3.C2H4O2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 54143-56-5
PubChem ID 41022
InChI Key RKXNZRPQSOPPRN-UHFFFAOYSA-N
Smiles CC(O)=O.FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(=C1)C(=O)NCC1CCCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.86 25
DMSO 47.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 474.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Banitt et al (1977) Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides. J.Med.Chem. 20 821 PMID: 874956

Rouet and Ducouret (1994) Use-and concentration-dependent effects of flecainide in guinea pig right ventricular muscle. J.Cardiovasc.Pharmacol. 24 177 PMID: 7526048

Singh et al (1984) The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. Ann.N.Y.Acad.Sci. 17 251 PMID: 6395762


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Keywords: Flecainide acetate, Flecainide acetate supplier, Cardiac, Na+, channel, blockers, Antiarrhythmic, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 1470, Tocris Bioscience

1 Citation for Flecainide acetate

Citations are publications that use Tocris products. Selected citations for Flecainide acetate include:

Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Neurosci 9 e96691 PMID: 24798465


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Literature in this Area

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