QX 314 chloride

Pricing Availability Delivery Time Qty
Cat.No. 2313 - QX 314 chloride | C16H27N2OCl | CAS No. 5369-03-9
Description: Na+ channel blocker
Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.

Technical Data

M. Wt 298.85
Formula C16H27N2OCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 5369-03-9
PubChem ID 21462
InChI Key LLPPOMUAOGMYQI-UHFFFAOYSA-N
Smiles [Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30 100

Preparing Stock Solutions

The following data is based on the product molecular weight 298.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.73 mL 33.46 mL
5 mM 0.67 mL 3.35 mL 6.69 mL
10 mM 0.33 mL 1.67 mL 3.35 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Stichartz et al (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 62 37 PMID: 4541340

Alreja and Aghajanian (1994) QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res. 639 320 PMID: 8205485

Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 72 911 PMID:


If you know of a relevant reference for QX 314 chloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Voltage-gated Sodium (NaV) Channel Blockers

Keywords: Na+ channel blockers Sodium NaV Channels voltage-gated voltage-dependent QX314 chloride Voltage-gated Sodium Channels

4 Citations for QX 314 chloride

Citations are publications that use Tocris products. Selected citations for QX 314 chloride include:

Wood et al (2009) Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. Front Cell Neurosci 29 12440 PMID: 19812320

Wang et al (2006) Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron 50 443 PMID: 16675398

Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. Mol Pain 9 115 PMID: 25918499

Cunningham et al (2014) hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell 15 559 PMID: 25517465


Do you know of a great paper that uses QX 314 chloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Pathways for QX 314 chloride

Protocols

TODO: Add Protocols