QX 314 chloride

Pricing Availability   Qty
Description: Na+ channel blocker
Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
Purity: ≥99% (HPLC)
Citations (9)
Reviews (2)
Literature (5)

Biological Activity for QX 314 chloride

QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.

Technical Data for QX 314 chloride

M. Wt 298.85
Formula C16H27N2OCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 5369-03-9
PubChem ID 21462
Smiles [Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for QX 314 chloride

Solvent Max Conc. mg/mL Max Conc. mM
water 30 100

Preparing Stock Solutions for QX 314 chloride

The following data is based on the product molecular weight 298.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.73 mL 33.46 mL
5 mM 0.67 mL 3.35 mL 6.69 mL
10 mM 0.33 mL 1.67 mL 3.35 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets for QX 314 chloride

Certificate of Analysis / Product Datasheet
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References for QX 314 chloride

References are publications that support the biological activity of the product.

Stichartz et al (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 62 37 PMID: 4541340

Alreja and Aghajanian (1994) QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res. 639 320 PMID: 8205485

Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 72 911 PMID: 7760149

If you know of a relevant reference for QX 314 chloride, please let us know.

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Keywords: QX 314 chloride, QX 314 chloride supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX314, chloride, Voltage-gated, 2313, Tocris Bioscience

9 Citations for QX 314 chloride

Citations are publications that use Tocris products. Selected citations for QX 314 chloride include:

Collins et al (2018) Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron 98 366 PMID: 29628187

Dong et al (2018) CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell Rep 24 284 PMID: 29996090

Birdsong et al (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife 8 PMID: 31099753

Wang et al (2006) DArgic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron 50 443 PMID: 16675398

Do you know of a great paper that uses QX 314 chloride from Tocris? Please let us know.

Reviews for QX 314 chloride

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Whole cell recordings with blocked action potentials.
By Anonymous on 05/08/2018
Assay Type: Ex Vivo
Species: Mouse

In whole cell electrophysiology experiments, we include this in our internal solution to block voltage gated sodium channels. Typically, we use 5-30 mM. Blockade is use-dependent. Drug needs some time and activity to be more effective. Picture is of a putative evoked EPSC in a cell held at +40mV with Qx-314 in internal solution.

review image

QX314+capsaicin blocks c fiber activities.
By Jing Feng on 01/10/2018
Assay Type: In Vivo
Species: Mouse

QX314 was used to block the activities of TRPV1-positive fibers in AEW-induced chronic itch model

QX314 should be injected with capsaicin.QX314: 200ug/mouseCapsaicin: 0.1%

review image

Literature in this Area

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