QX 314 chloride

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Cat.No. 2313 - QX 314 chloride | C16H27N2OCl | CAS No. 5369-03-9
Description: Na+ channel blocker
Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
Purity: ≥99% (HPLC)
Datasheet
Citations (8)
Reviews (2)
Literature (5)

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.

Technical Data

M. Wt 298.85
Formula C16H27N2OCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 5369-03-9
PubChem ID 21462
InChI Key LLPPOMUAOGMYQI-UHFFFAOYSA-N
Smiles [Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30 100

Preparing Stock Solutions

The following data is based on the product molecular weight 298.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.73 mL 33.46 mL
5 mM 0.67 mL 3.35 mL 6.69 mL
10 mM 0.33 mL 1.67 mL 3.35 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Stichartz et al (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 62 37 PMID: 4541340

Alreja and Aghajanian (1994) QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res. 639 320 PMID: 8205485

Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 72 911 PMID: 7760149


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Keywords: QX 314 chloride, QX 314 chloride supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX314, chloride, Voltage-gated, 2313, Tocris Bioscience

8 Citations for QX 314 chloride

Citations are publications that use Tocris products. Selected citations for QX 314 chloride include:

Arvin et al (2019) Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine. J Vis Exp 143 e58873 PMID: 30735191

Birdsong et al (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife 8 PMID: 31099753

Hull (2017) Measuring Feedforward Inhibition and Its Impact on Local Circuit Function. Cold Spring Harb Protoc 2017 PMID: 28461661

Dong et al (2018) CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell Rep 24 284 PMID: 29996090

Cunningham et al (2014) hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell 15 559 PMID: 25517465

Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. Mol Pain 9 115 PMID: 25918499

Wang et al (2006) DArgic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron 50 443 PMID: 16675398

Wood et al (2009) Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. Front Cell Neurosci 29 12440 PMID: 19812320


Do you know of a great paper that uses QX 314 chloride from Tocris? Please let us know.

Reviews for QX 314 chloride

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Whole cell recordings with blocked action potentials.
By Anonymous on 05/08/2018
Assay Type: Ex Vivo
Species: Mouse

In whole cell electrophysiology experiments, we include this in our internal solution to block voltage gated sodium channels. Typically, we use 5-30 mM. Blockade is use-dependent. Drug needs some time and activity to be more effective. Picture is of a putative evoked EPSC in a cell held at +40mV with Qx-314 in internal solution.

review image

QX314+capsaicin blocks c fiber activities.
By Jing Feng on 01/10/2018
Assay Type: In Vivo
Species: Mouse

QX314 was used to block the activities of TRPV1-positive fibers in AEW-induced chronic itch model

QX314 should be injected with capsaicin.QX314: 200ug/mouseCapsaicin: 0.1%

review image

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