Mexiletine hydrochloride

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Cat.No. 2596 - Mexiletine hydrochloride | C11H17NO.HCl | CAS No. 5370-01-4
Description: Na+ channel blocker; antiarrhythmic agent
Alternative Names: Ko 1173
Chemical Name: 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

Use-dependent sodium channel blocker (IC50 values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.

Compound Libraries

Mexiletine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 215.72
Formula C11H17NO.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 5370-01-4
PubChem ID 21467
Smiles Cl.CC(N)COC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.57 100
ethanol 21.57 100
water 21.57 100

Preparing Stock Solutions

The following data is based on the product molecular weight 215.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.64 mL 23.18 mL 46.36 mL
5 mM 0.93 mL 4.64 mL 9.27 mL
10 mM 0.46 mL 2.32 mL 4.64 mL
50 mM 0.09 mL 0.46 mL 0.93 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Franchini et al (2003) Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels. J.Med.Chem. 46 5238 PMID: 14613326

Ates et al (2006) Neuroprotective effect of mexiletine in the central nervous system of diabetic rats. Mol.Cell.Biochem. 286 125 PMID: 16541198

Bellis et al (2006) Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents. Br.J.Pharmacol. 149 300 PMID: 16921388

If you know of a relevant reference for Mexiletine hydrochloride, please let us know.

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2 Citations for Mexiletine hydrochloride

Citations are publications that use Tocris products. Selected citations for Mexiletine hydrochloride include:

Rojas et al (2015) Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling. Front Cell Neurosci 9 203 PMID: 26106294

Rojas et al (2014) Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress. Front Cell Neurosci 8 24 PMID: 24570655

Do you know of a great paper that uses Mexiletine hydrochloride from Tocris? If so please let us know.

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