Use-dependent sodium channel blocker (IC50 values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 215.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.64 mL||23.18 mL||46.36 mL|
|5 mM||0.93 mL||4.64 mL||9.27 mL|
|10 mM||0.46 mL||2.32 mL||4.64 mL|
|50 mM||0.09 mL||0.46 mL||0.93 mL|
References are publications that support the products' biological activity.
Franchini et al (2003) Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels. J.Med.Chem. 46 5238 PMID: 14613326
Ates et al (2006) Neuroprotective effect of mexiletine in the central nervous system of diabetic rats. Mol.Cell.Biochem. 286 125 PMID: 16541198
Bellis et al (2006) Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents. Br.J.Pharmacol. 149 300 PMID: 16921388
If you know of a relevant reference for Mexiletine hydrochloride, please let us know.
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Keywords: Mexiletine hydrochloride, supplier, Na+, channel, blockers, antiarrhythmic, agent, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Ko1173, Ko, 1173, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience
2 Citations for Mexiletine hydrochloride
Citations are publications that use Tocris products. Selected citations for Mexiletine hydrochloride include:
Rojas et al (2014) Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress. Front Cell Neurosci 8 24 PMID: 24570655
Rojas et al (2015) Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling. Front Cell Neurosci 9 203 PMID: 26106294
Do you know of a great paper that uses Mexiletine hydrochloride from Tocris? If so please let us know.
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Literature in this Area
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