Mexiletine hydrochloride

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Description: Na+ channel blocker; antiarrhythmic agent
Alternative Names: Ko 1173
Chemical Name: 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for Mexiletine hydrochloride

Mexiletine hydrochloride is an use-dependent sodium channel blocker (IC50 values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.

Compound Libraries for Mexiletine hydrochloride

Mexiletine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Mexiletine hydrochloride

M. Wt 215.72
Formula C11H17NO.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 5370-01-4
PubChem ID 21467
InChI Key NFEIBWMZVIVJLQ-UHFFFAOYSA-N
Smiles Cl.CC(N)COC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mexiletine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 21.57 100
DMSO 21.57 100

Preparing Stock Solutions for Mexiletine hydrochloride

The following data is based on the product molecular weight 215.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.64 mL 23.18 mL 46.36 mL
5 mM 0.93 mL 4.64 mL 9.27 mL
10 mM 0.46 mL 2.32 mL 4.64 mL
50 mM 0.09 mL 0.46 mL 0.93 mL

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Product Datasheets for Mexiletine hydrochloride

References for Mexiletine hydrochloride

References are publications that support the biological activity of the product.

Franchini et al (2003) Optically active mexil. analogues as stereoselective blockers of voltage-gated Na+ channels. J.Med.Chem. 46 5238 PMID: 14613326

Ates et al (2006) Neuroprotective effect of mexil. in the central nervous system of diabetic rats. Mol.Cell.Biochem. 286 125 PMID: 16541198

Bellis et al (2006) Evaluation of the pharmacological activity of the major mexil. metabolites on skeletal muscle sodium currents. Br.J.Pharmacol. 149 300 PMID: 16921388


If you know of a relevant reference for Mexiletine hydrochloride, please let us know.

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2 Citations for Mexiletine hydrochloride

Citations are publications that use Tocris products. Selected citations for Mexiletine hydrochloride include:

Rojas et al (2014) Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress. Front Cell Neurosci 8 24 PMID: 24570655

Rojas et al (2015) Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling. Front Cell Neurosci 9 203 PMID: 26106294


Do you know of a great paper that uses Mexiletine hydrochloride from Tocris? Please let us know.

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