A 803467

Pricing Availability   Qty
Description: Selective NaV1.8 channel blocker
Chemical Name: 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews
Literature (5)

Biological Activity for A 803467

A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

Compound Libraries for A 803467

A 803467 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 803467

M. Wt 357.79
Formula C19H16ClNO4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 944261-79-4
PubChem ID 16038374
InChI Key VHKBTPQDHDSBSP-UHFFFAOYSA-N
Smiles ClC(C=C2)=CC=C2C1=CC=C(C(NC3=CC(OC)=CC(OC)=C3)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 803467

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.78 100
ethanol 8.94 25

Preparing Stock Solutions for A 803467

The following data is based on the product molecular weight 357.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.97 mL 27.95 mL
5 mM 0.56 mL 2.79 mL 5.59 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for A 803467

Certificate of Analysis / Product Datasheet
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Keywords: A 803467, A 803467 supplier, Selective, NaV18, blockers, Sodium, Channels, voltage-gated, voltage-dependent, Na+, A803467, Voltage-gated, 2976, Tocris Bioscience

7 Citations for A 803467

Citations are publications that use Tocris products. Selected citations for A 803467 include:

Wu et al (2016) CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain Scientific Reports 6 34836 PMID: 27708397

Bladen (2012) Common mechanisms of drug interactions with sodium and T-type calcium channels. Mol Pharmacol 82 481 PMID: 22695716

Schuelert and McDougall (2012) Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis. Arthritis Res Ther 14 R5 PMID: 22225591

Curtright et al (2015) Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS One 10 e0116766 PMID: 25587718


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Literature in this Area

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