A 803467

Pricing Availability   Qty
Description: Selective NaV1.8 channel blocker
Chemical Name: 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews

Biological Activity for A 803467

A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

Compound Libraries for A 803467

A 803467 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 803467

M. Wt 357.79
Formula C19H16ClNO4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 944261-79-4
PubChem ID 16038374
InChI Key VHKBTPQDHDSBSP-UHFFFAOYSA-N
Smiles ClC(C=C2)=CC=C2C1=CC=C(C(NC3=CC(OC)=CC(OC)=C3)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 803467

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.78 100
ethanol 8.94 25

Preparing Stock Solutions for A 803467

The following data is based on the product molecular weight 357.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.97 mL 27.95 mL
5 mM 0.56 mL 2.79 mL 5.59 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for A 803467

Certificate of Analysis / Product Datasheet
Select another batch:

View Related Products by Target

View Related Products by Product Action

View all Voltage-gated Sodium (NaV) Channel Blockers

Keywords: A 803467, A 803467 supplier, Selective, NaV18, blockers, Sodium, Channels, voltage-gated, voltage-dependent, Na+, A803467, Voltage-gated, 2976, Tocris Bioscience

7 Citations for A 803467

Citations are publications that use Tocris products. Selected citations for A 803467 include:

Bladen (2012) Common mechanisms of drug interactions with sodium and T-type calcium channels. Mol Pharmacol 82 481 PMID: 22695716

Wu et al (2016) CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain Scientific Reports 6 34836 PMID: 27708397

Liu et al (2014) Functional upregulation of nav1.8 sodium channels on the membrane of dorsal root Ganglia neurons contributes to the development of cancer-induced bone pain. PLoS One 9 e114623 PMID: 25503076

Mascanfroni et al (2015) Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α. Biol Open 21 638 PMID: 26005855


Do you know of a great paper that uses A 803467 from Tocris? Please let us know.

Reviews for A 803467

There are currently no reviews for this product. Be the first to review A 803467 and earn rewards!

Have you used A 803467?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review