PF 04885614

Pricing Availability   Qty
Description: Potent and selective NaV1.8 channel blocker; active in vivo
Chemical Name: 1-Methyl-1-[4-(4-trifluoromethoxy-phenyl)-1H-imidazol-2-yl]-ethylamine
Purity: ≥98% (HPLC)
Reviews (1)

Biological Activity for PF 04885614

PF 04885614 is a potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 04885614

PF 04885614 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PF 04885614

M. Wt 285.26
Formula C13H14F3N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1480833-70-2
PubChem ID 65459349
Smiles CC(C)(N)C1=NC(C2=CC=C(OC(F)(F)F)C=C2)=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 04885614

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.53 100
ethanol 28.53 100

Preparing Stock Solutions for PF 04885614

The following data is based on the product molecular weight 285.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets for PF 04885614

Certificate of Analysis / Product Datasheet
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References for PF 04885614

References are publications that support the biological activity of the product.

Bagal et al (2013) Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract. 4th RSC/SCI Symp. on Ion Channels as Ther. Targ

If you know of a relevant reference for PF 04885614, please let us know.

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Citations for PF 04885614

Citations are publications that use Tocris products.

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Reviews for PF 04885614

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PF 04885614 used to understand the modulation of peripheral sensitisation.
By Alex Samuel on 01/16/2020
Species: Human

PF 04885614 as an inhibitor was used to understand the modulation of peripheral sensitisation.

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