You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 285.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.51 mL||17.53 mL||35.06 mL|
|5 mM||0.7 mL||3.51 mL||7.01 mL|
|10 mM||0.35 mL||1.75 mL||3.51 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References are publications that support the biological activity of the product.
Bagal et al (2013) Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract. 4th RSC/SCI Symp. on Ion Channels as Ther. Targ
If you know of a relevant reference for PF 04885614, please let us know.
View Related Products by Product Action
Keywords: PF 04885614, PF 04885614 supplier, PF04885614, NaV1.8, voltage, gated, sodium, channel, inhibitors, inhibits, potent, selective, in, vivo, efficacy, antinociceptive, analgesic, Voltage-gated, Sodium, Channels, 4916, Tocris Bioscience
Citations for PF 04885614
Citations are publications that use Tocris products.
Currently there are no citations for PF 04885614. Do you know of a great paper that uses PF 04885614 from Tocris? Please let us know.
Reviews for PF 04885614
There are currently no reviews for this product. Be the first to review PF 04885614 and earn rewards!
Have you used PF 04885614?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.