PF 04885614

Pricing Availability Delivery Time Qty
Cat.No. 4916 - PF 04885614 | C13H14F3N3O
Description: Potent and selective NaV1.8 channel blocker; active in vivo
Chemical Name: 1-Methyl-[1-[4-(4-trifluoromethoxy)phenyl]-imidazol-2-yl]-ethanamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

PF 04885614 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 285.26
Formula C13H14F3N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 65459349
InChI Key AGORGFNWYAUYSU-UHFFFAOYSA-N
Smiles CC(C)(N)C1=NC(C2=CC=C(OC(F)(F)F)C=C2)=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.53 100
ethanol 28.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 285.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bagal et al (2013) Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract. 4th RSC/SCI Symp. on Ion Channels as Ther. Targ PMID:


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Citations for PF 04885614

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