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Description: Potent and selective NaV1.3 and NaV1.1 channel blocker
Chemical Name: α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide
Purity: ≥98% (HPLC)
Biological Activity for ICA 121431
ICA 121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50 values are >10 μM for human NaV1.5 and NaV1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.
Compound Libraries for ICA 121431
ICA 121431 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ICA 121431
| M. Wt | 449.55 |
| Formula | C23H19N3O3S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 313254-51-2 |
| PubChem ID | 998021 |
| InChI Key | URSQNPPONHUJDL-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=C(NC(C(C4=CC=CC=C4)C3=CC=CC=C3)=O)C=C1)(NC2=NC=CS2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ICA 121431
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.95 | 100 |
Preparing Stock Solutions for ICA 121431
The following data is based on the product molecular weight 449.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.12 mL | 22.24 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets for ICA 121431
References for ICA 121431
References are publications that support the biological activity of the product.
McCormack et al (2013) Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc.Natl.Acad.Sci. 110 2724 PMID: 23818614
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Keywords: ICA 121431, ICA 121431 supplier, Selective, NaV, blockers, Sodium, Channels, voltage-gated, voltage-dependent, Na+, ICA121431, Voltage-gated, 5066, Tocris Bioscience
1 Citation for ICA 121431
Citations are publications that use Tocris products. Selected citations for ICA 121431 include:
Kocmalova et al (2017) Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves. J Pharmacol Exp Ther 361 172 PMID: 28138042
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