ICA 121431

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Cat.No. 5066 - ICA 121431 | C23H19N3O3S2 | CAS No. 313254-51-2
Description: Potent and selective NaV1.3 and NaV1.1 channel blocker
Chemical Name: α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50 values are >10 μM for human NaV1.5 and NaV1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.

Compound Libraries

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Technical Data

M. Wt 449.55
Formula C23H19N3O3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 313254-51-2
PubChem ID 998021
InChI Key URSQNPPONHUJDL-UHFFFAOYSA-N
Smiles O=S(C1=CC=C(NC(C(C4=CC=CC=C4)C3=CC=CC=C3)=O)C=C1)(NC2=NC=CS2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 449.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.12 mL 22.24 mL
5 mM 0.44 mL 2.22 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

McCormack et al (2013) Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc.Natl.Acad.Sci. 110 2724 PMID: 23818614


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Keywords: ICA 121431, ICA 121431 supplier, Selective, NaV, blockers, Sodium, Channels, voltage-gated, voltage-dependent, Na+, ICA121431, Voltage-gated, 5066, Tocris Bioscience

Citations for ICA 121431

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