Pricing Availability   Qty
Description: Na+ channel blocker
Chemical Name: 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
Purity: ≥99% (HPLC)
Citations (2)
Reviews (1)

Biological Activity for Lidocaine

Lidocaine is an anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.

Technical Data for Lidocaine

M. Wt 234.34
Formula C14H22N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 137-58-6
PubChem ID 3676
Smiles O=C(CN(CC)CC)NC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lidocaine

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 23.43 100
DMSO 23.43 100

Preparing Stock Solutions for Lidocaine

The following data is based on the product molecular weight 234.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.67 mL
5 mM 0.85 mL 4.27 mL 8.53 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Lidocaine

Certificate of Analysis / Product Datasheet
Select another batch:

References for Lidocaine

References are publications that support the biological activity of the product.

Sarraf et al (2003) Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats. Br.J.Pharmacol. 139 1389 PMID: 12922925

If you know of a relevant reference for Lidocaine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Voltage-gated Sodium (NaV) Channel Blockers

Keywords: Lidocaine, Lidocaine supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 3057, Tocris Bioscience

2 Citations for Lidocaine

Citations are publications that use Tocris products. Selected citations for Lidocaine include:

Miguel Angel Garcia-Bereguiain et al (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience 6 7268 PMID: 27383600

Hernández-Cascales (2017) Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium. PeerJ 5 e3113 PMID: 28382232

Do you know of a great paper that uses Lidocaine from Tocris? Please let us know.

Reviews for Lidocaine

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used Lidocaine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Lidocaine in prelimbic medial prefrontal cortex blocks cue-induced reinstatement of MDMA seeking.
By Kevin Ball on 01/25/2019
Assay Type: In Vivo
Species: Rat

Bilateral microinjections of lidocaine (100 micrograms/0.5 microliter/side) into prelimbic, but not infralimbic, medial prefrontal cortex blocked cue-induced reinstatement of MDMA (ecstasy)-seeking behavior compared with saline microinjections into the same region. Lidocaine microinjections into either region did not, however, have an effect on food-maintained responding, ruling out a nonspecific disruption of motor performance.

PMID: 4078904 Reference
review image