Lidocaine

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Cat.No. 3057 - Lidocaine | C14H22N2O | CAS No. 137-58-6
Description: Na+ channel blocker
Chemical Name: 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.

Technical Data

M. Wt 234.34
Formula C14H22N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 137-58-6
PubChem ID 3676
InChI Key NNJVILVZKWQKPM-UHFFFAOYSA-N
Smiles O=C(CN(CC)CC)NC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 23.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 234.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.67 mL
5 mM 0.85 mL 4.27 mL 8.53 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Sarraf et al (2003) Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats. Br.J.Pharmacol. 139 1389 PMID: 12922925


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View all Voltage-gated Sodium (NaV) Channel Blockers

Keywords: Lidocaine, Lidocaine supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 3057, Tocris Bioscience

1 Citation for Lidocaine

Citations are publications that use Tocris products. Selected citations for Lidocaine include:

Miguel Angel Garcia-Bereguiain et al (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience 6 7268 PMID: 27383600


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