Phosphodiesterases

Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
2432 Anagrelide hydrochloride
Potent PDE3 inhibitor
4496 BC 11-38
Selective PDE11 inhibitor
2237 BRL 50481
Selective PDE7 inhibitor
2793 Caffeine
Cyclic nucleotide PDE inhibitor
4420 Carbazeran citrate
Aldehyde oxidase substrate; PDE inhibitor
3936 CDP 840 hydrochloride
Potent and selective PDE4 inhibitor
2344 CGH 2466 dihydrochloride
Anti-inflammatory agent. Inhibitor of PDE4 and p38 MAPK, also adenosine receptor antagonist
0915 Cilostamide
PDE3 inhibitor
1692 Cilostazol
PDE3A inhibitor. Also adenosine uptake inhibitor
2729 CP 80633
Selective PDE4 inhibitor
0691 Dipyridamole
PDE5/6/8/10/11 inhibitor
5695 Eggmanone
Potent and selective PDE4 inhibitor; suppresses hedgehog signaling
1261 EHNA hydrochloride
PDE2 inhibitor
1693 Enoximone
PDE3 inhibitor
0438 Etazolate hydrochloride
PDE4 inhibitor
4165 Gisadenafil besylate
Potent PDE5 inhibitor; orally bioavailable
2845 IBMX
PDE inhibitor (non-selective)
1694 Ibudilast
PDE inhibitor (non-selective)
1816 ICI 63197
PDE4 inhibitor
2504 Irsogladine maleate
PDE4 inhibitor; antiulcer agent
1436 MDL 12330A hydrochloride
Cyclic nucleotide PDE inhibitor; also adenylyl cyclase inhibitor
3053 Mesopram
Orally active PDE4 inhibitor
1504 Milrinone
PDE3 inhibitor
0552 MMPX
PDE1 inhibitor
0432 MY-5445
PDE5 inhibitor
3056 Pentoxifylline
PDE inhibitor
5915 PF 04449613
Potent PDE9 inhibitor; brain penetrant
4525 Piclamilast
Potent and selective PDE4 inhibitor
0415 Ro 20-1724
PDE4 inhibitor
0905 Rolipram
PDE4 inhibitor
1349 (R)-(-)-Rolipram
PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)
1350 (S)-(+)-Rolipram
PDE4 inhibitor. Less active enantiomer of rolipram (Cat. No. 0905)
3315 RS 25344 hydrochloride
Potent PDE4 inhibitor
1148 Siguazodan
PDE3 inhibitor
3784 Sildenafil citrate
Orally active, potent PDE5 inhibitor
1676 T 0156 hydrochloride
Highly potent, selective PDE5 inhibitor
6311 Tadalafil
Potent and highly selective PDE5 inhibitor; orally bioavailable
4572 TC-E 5005
Potent and selective PDE10A inhibitor
2795 Theophylline
Phosphodiesterase inhibitor
2337 Trequinsin hydrochloride
Extremely potent inhibitor of PDE3
0757 Vinpocetine
PDE1 inhibitor
1821 YM 976
PDE4 inhibitor
0947 Zaprinast
PDE5/6/9/11 inhibitor
1046 Zardaverine
PDE3/4 inhibitor

Ligand-sets

Cat No Product Name / Activity
1881 Phosphodiesterase Inhibitor Tocriset™
Selection of 5 phosphodiesterase inhibitors (Cat. Nos. 0915, 1504, 0415, 1349 and 1046)

Other

Cat No Product Name / Activity
5424 Deltarasin
High affinity PDEδ-KRAS interaction inhibitor

Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation.

There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

External sources of pharmacological information for Phosphodiesterases :

    Literature for Phosphodiesterases

    Cardiovascular

    Cardiovascular Research Product Guide

    A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

    • Hypertension
    • Thrombosis and Hemostasis
    • Atherosclerosis
    • Myocardial Infarction
    • Ischemia/Reperfusion Injury
    • Arrhythmias
    • Heart Failure
    Asthma

    Asthma Poster

    Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

    Phosphodiesterase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    PDE1A Human PDE1A NM_005019 Q9C0L4
    Mouse Pde1a NM_016744 Q61481
    Rat Pde1a NM_030871 Q9EPR9
    PDE1B Human PDE1B NM_000924 Q01064
    Mouse Pde1b NM_008800 Q01065
    Rat Pde1b NM_022710 Q01066
    PDE1C Human PDE1C NM_005020 Q14123
    Mouse Pde1c NM_001025568 Q64338
    Rat Pde1c NM_031078 Q63421
    PDE2A Human PDE2A NM_002599 O00408
    Mouse Pde2a NM_001008548 Q922S4
    Rat Pde2a NM_031079 Q01062
    PDE3A Human PDE3A NM_000921 Q14432
    Mouse Pde3a NM_018779 Q9Z0X4
    Rat Pde3a NM_017337 Q62865
    PDE3B Human PDE3B NM_000922 Q13370
    Mouse Pde3b NM_011055 Q61409
    Rat Pde3b NM_017229 Q63085
    PDE4A Human PDE4A NM_001111309 P27815
    Mouse Pde4a NM_183408 O89084
    Rat Pde4a NM_013101 P54748
    PDE4B Human PDE4B NM_002600 Q07343
    Mouse Pde4b NM_019840 NP_062814
    Rat Pde4b NM_017031 P14646
    PDE4C Human PDE4C NM_001098818 Q08493
    Mouse Pde4c NM_201607 Q3UEI1
    Rat Pde4c XM_214325 P14644
    PDE4D Human PDE4D NM_001104631 Q8IVD2
    Mouse Pde4d AK032648 Q01063
    Rat Pde4d NM_017032 P14270
    PDE5A Human PDE5A NM_001083 O76074
    Mouse Pde5a NM_153422 Q8CG03
    Rat Pde5a NM_133584 O54735
    PDE6A Human PDE6A NM_000440 P16499
    Mouse Pde6a NM_146086 P27664
    Rat Pde6a NM_001107386 XP_225895
    PDE6B Human PDE6B NM_000283 P35913
    Mouse Pde6b NM_008806 P23440
    Rat Pde6b NM_001106024 XP_214126
    PDE6C Human PDE6C NM_006204 P51160
    Mouse Pde6c NM_033614 Q91ZQ1
    Rat Pde6c NM_001108522 XP_342047
    PDE6D Human PDE6D NM_002601 O43924
    Mouse Pde6d NM_008801 O55057
    Rat Pde6d NM_001108806 XP_343614
    PDE6G Human PDE6G NM_002602 P18545
    Mouse Pde6g NM_012065 P09174
    PDE6H Human PDE6H NM_006205 Q13956
    Mouse Pde6h NM_023898 P61249
    Rat Pde6h NM_053688 P61250
    PDE7A Human PDE7A NM_002603 Q13946
    Mouse Pde7a NM_001122759 P70453
    Rat Pde7a XM_215540 O08593
    PDE7B Human PDE7B NM_018945 Q9NP56
    Mouse Pde7b NM_013875 Q9QXQ1
    Rat Pde7b NM_080894 Q8VIE2
    PDE8A Human PDE8A NM_002605 O60658
    Mouse Pde8a NM_008803 O88502
    Rat Pde8a NM_198767 Q76KC6
    PDE8B Human PDE8B NM_003719 O95263
    Mouse Pde8b NM_172263 NP_758467
    Rat Pde8b NM_199268 Q76KC5
    PDE9A Human PDE9A NM_001001585 Q86WN4
    Mouse Pde9a NM_008804 O70628
    Rat Pde9a NM_138543 Q8QZV1
    PDE10A Human PDE10A NM_006661 Q9Y233
    Mouse Pde10a NM_011866 Q8CA95
    Rat Pde10a NM_022236 Q9QYJ6
    PDE11A Human PDE11A NM_001077358 Q9HCR9
    Mouse Pde11a NM_001081033 P0C1Q2
    Rat Pde11a NM_080893 Q8VID6