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Coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC50 values are 0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC50 = 144.8 nM and Ki = 8.18 nM for ENT1).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 100 mM in DMSO and to 10 mM in ethanol|
References are publications that support the biological activity of the product.
Fujishige et al (1999) Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J.Biol.Chem. 274 18438 PMID: 10373451
Meester et al (1998) Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig. Br.J.Pharmacol. 124 729 PMID: 9690865
Soderling et al (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 95 8991 PMID: 9671792
Lin and Buolamwini et al (2007) Synthesis, flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949
If you know of a relevant reference for Dipyridamole, please let us know.
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Keywords: Dipyridamole, Dipyridamole supplier, adenosines, transport, inhibitors, inhibits, PDE5, 6, 10, 8, 11, ENT1, Uptake, Purine, Transporters, Pyrimidine, Equilibrative, Nucleoside, Monoamine, Neurotransmitter, Phosphodiesterases, vasodilator, 0691, Tocris Bioscience
3 Citations for Dipyridamole
Citations are publications that use Tocris products. Selected citations for Dipyridamole include:
Cunha et al (2015) Creatine, similarly to KA, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation. Sci Rep 11 215 PMID: 25702084
Nguyen et al (2015) Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism. Pharmacol Res Perspect 3 e00189 PMID: 27022463
Davidson et al (2016) Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass PLoS One 11 e0158981 PMID: 27384524
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