Dipyridamole

Pricing Availability Delivery Time Qty
Cat.No. 0691 - Dipyridamole | C24H40N8O4 | CAS No. 58-32-2
Description: Adenosine transport inhibitor
Chemical Name: 2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC50 values are 0.37, 0.38, 0.45, 0.9 and 4.5 μM  for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC50 = 144.8 nM and Ki = 8.18 nM for ENT1).

Compound Libraries

Dipyridamole is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 504.63
Formula C24H40N8O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 58-32-2
PubChem ID 3108
InChI Key IZEKFCXSFNUWAM-UHFFFAOYSA-N
Smiles OCCN(CCO)C1=NC(N2CCCCC2)=C2N=C(N=C(N3CCCCC3)C2=N1)N(CCO)CCO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO and to 10 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 504.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fujishige et al (1999) Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J.Biol.Chem. 274 18438 PMID: 10373451

Meester et al (1998) Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig. Br.J.Pharmacol. 124 729 PMID: 9690865

Soderling et al (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 95 8991 PMID: 9671792

Lin and Buolamwini et al (2007) Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949


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View all Nucleoside Transporter Inhibitors

Keywords: Dipyridamole, supplier, adenosines, transport, inhibitors, inhibits, PDE5, 6, 10, 8, 11, ENT1, Uptake, Purine, Transporters, Pyrimidine, Equilibrative, Nucleoside, Monoamine, Neurotransmitter, Phosphodiesterases, vasodilator, Nucleoside, Transporters, Phosphodiesterases, Nucleoside, Transporters, Tocris Bioscience

2 Citations for Dipyridamole

Citations are publications that use Tocris products. Selected citations for Dipyridamole include:

Davidson et al (2016) Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass PLoS One 11 e0158981 PMID: 27384524

Cunha et al (2015) Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation. Sci Rep 11 215 PMID: 25702084


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