Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTrequinsin hydrochloride
Description: Highly potent PDE3 inhibitor
Alternative Names: HL-725
Chemical Name: 2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride
Purity: ≥97% (HPLC)
Biological Activity for Trequinsin hydrochloride
Trequinsin hydrochloride is a highly potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models. Also activates CatSper channels, increases intracellular Ca2+ and cGMP levels, and decreases potassium channel activity in sperm.
Compound Libraries for Trequinsin hydrochloride
Trequinsin hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Trequinsin hydrochloride
| M. Wt | 441.95 |
| Formula | C24H27N3O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 78416-81-6 |
| PubChem ID | 3060974 |
| InChI Key | DTCZZBVPTHVXFA-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(OC)C=C2C(CCN3C(=O)N(C)C(\C=C23)=N\C2=C(C)C=C(C)C=C2C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Trequinsin hydrochloride
References for Trequinsin hydrochloride
References are publications that support the biological activity of the product.
Ruppert and Weithmann (1982) HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro. Life Sci. 31 2037 PMID: 6294426
Lal et al (1984) Trequinsin, a potent new antihypertensive vasodilator in the series of 2-(arylimino)-3-alkyl-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-ones. J.Med.Chem. 27 1470 PMID: 6492077
Agarwal et al (1987) Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences. Thromb.Res. 47 191 PMID: 2821650
McBrinn et al (2019) Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function. Br.J.Pharmacol. PMID: 31368510
View Related Products by Target
View Related Products by Product Action
Keywords: Trequinsin hydrochloride, Trequinsin hydrochloride supplier, Ultrapotent, inhibitors, inhibits, PDE3, Phosphodiesterases, HL725, Catsper, activators, activates, sperm, motility, HL-725, Other, Calcium, Channels, 2337, Tocris Bioscience
1 Citation for Trequinsin hydrochloride
Citations are publications that use Tocris products. Selected citations for Trequinsin hydrochloride include:
McBrinn et al (2019) Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function. Br.J.Pharmacol. 176 4521 PMID: 31368510
Reviews for Trequinsin hydrochloride
There are currently no reviews for this product. Be the first to review Trequinsin hydrochloride and earn rewards!
Have you used Trequinsin hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image