Enoximone
Biological Activity
Inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro.
Technical Data
| M. Wt | 248.3 |
| Formula | C12H12N2O2S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 77671-31-9 |
| PubChem ID | 53708 |
| InChI Key | ZJKNESGOIKRXQY-UHFFFAOYSA-N |
| Smiles | CC(NC(N2)=O)=C2C(C1=CC=C(SC)C=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 248.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.03 mL | 20.14 mL | 40.27 mL |
| 5 mM | 0.81 mL | 4.03 mL | 8.05 mL |
| 10 mM | 0.4 mL | 2.01 mL | 4.03 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Jung et al (2005) Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, o J.Pharmacol.Exp.Ther. 312 517 PMID: 15550574
Pacher and Stanek (1999) Ambulatory vasodilator therapy in heart failure: systematic review of the literature and personal observational experience. Eur.J.Heart Fail. 1 263 PMID: 10935673
Vroom et al (1996) Effect of phosphodiesterase inhibitors on human arteries in vitro. Br.J.Anaesth. 76 122 PMID: 8672353
If you know of a relevant reference for Enoximone, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Enoximone, Enoximone supplier, phosphodiesterases, pde3, pdeIII, inhibitors, inhibits, Phosphodiesterases, 1693, Tocris Bioscience
Citations for Enoximone
Citations are publications that use Tocris products.
Currently there are no citations for Enoximone. Do you know of a great paper that uses Enoximone from Tocris? Please let us know.
Reviews for Enoximone
There are currently no reviews for this product. Be the first to review Enoximone and earn rewards!
Have you used Enoximone?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
Asthma Poster
Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.
