Enoximone

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Cat.No. 1693 - Enoximone | C12H12N2O2S | CAS No. 77671-31-9
Description: PDE3 inhibitor
Chemical Name: 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro.

Technical Data

M. Wt 248.3
Formula C12H12N2O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 77671-31-9
PubChem ID 53708
InChI Key ZJKNESGOIKRXQY-UHFFFAOYSA-N
Smiles CC(NC(N2)=O)=C2C(C1=CC=C(SC)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 248.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Jung et al (2005) Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, o J.Pharmacol.Exp.Ther. 312 517 PMID: 15550574

Pacher and Stanek (1999) Ambulatory vasodilator therapy in heart failure: systematic review of the literature and personal observational experience. Eur.J.Heart Fail. 1 263 PMID: 10935673

Vroom et al (1996) Effect of phosphodiesterase inhibitors on human arteries in vitro. Br.J.Anaesth. 76 122 PMID: 8672353


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Keywords: Enoximone, supplier, phosphodiesterases, pde3, pdeIII, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience

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Cardiovascular

Cardiovascular Research Product Guide

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  • Thrombosis and Hemostasis
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  • Myocardial Infarction
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