Home / Pharmacology / Enzymes / Phosphodiesterases / Phosphodiesterase Inhibitors / Enoximone

Enoximone

Cat. No. 1693 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: PDE3 inhibitor
Chemical Name: 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Enoximone

Enoximone is an inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro.

Technical Data for Enoximone

M. Wt 248.3
Formula C12H12N2O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 77671-31-9
PubChem ID 53708
InChI Key ZJKNESGOIKRXQY-UHFFFAOYSA-N
Smiles CC(NC(N2)=O)=C2C(C1=CC=C(SC)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Enoximone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.83 100

Preparing Stock Solutions for Enoximone

The following data is based on the product molecular weight 248.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Enoximone

References are publications that support the biological activity of the product.

Jung et al (2005) Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, o J.Pharmacol.Exp.Ther. 312 517 PMID: 15550574

Pacher and Stanek (1999) Ambulatory vasodilator therapy in heart failure: systematic review of the literature and personal observational experience. Eur.J.Heart Fail. 1 263 PMID: 10935673

Vroom et al (1996) Effect of phosphodiesterase inhibitors on human arteries in vitro. Br.J.Anaesth. 76 122 PMID: 8672353

If you know of a relevant reference for Enoximone, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phosphodiesterase Inhibitors

Keywords: Enoximone, Enoximone supplier, phosphodiesterases, pde3, pdeIII, inhibitors, inhibits, Phosphodiesterases, 1693, Tocris Bioscience

Citations for Enoximone

Citations are publications that use Tocris products.

Currently there are no citations for Enoximone. Do you know of a great paper that uses Enoximone from Tocris? Please let us know.

Reviews for Enoximone

There are currently no reviews for this product. Be the first to review Enoximone and earn rewards!

Have you used Enoximone?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review