You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
PF 04671536 hydrochloride
Potent and selective PDE8B/8A inhibitor ( IC50 values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC50 values are >10 μM) and a range of other targets. Increases glucose-dependent insulin secretion from human pacreatic islet cells. Orally bioavailable.
Sold for research purposes under agreement from Pfizer Inc
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||7.66||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 382.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.61 mL||13.06 mL||26.12 mL|
|5 mM||0.52 mL||2.61 mL||5.22 mL|
|10 mM||0.26 mL||1.31 mL||2.61 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
References are publications that support the biological activity of the product.
DeNinno et al (2012) Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg.Med.Chem.Lett. 22 5721 PMID: 22858141
If you know of a relevant reference for PF 04671536 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PF 04671536 hydrochloride, PF 04671536 hydrochloride supplier, PF04671536, hydrochloride, diabetes, phosphodiesterase, 8A, 8B, PDE, potent, selective, orally, bioavailable, antidiabetics, inhibitors, inhibits, Phosphodiesterases, 6024, Tocris Bioscience
Citations for PF 04671536 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for PF 04671536 hydrochloride. Do you know of a great paper that uses PF 04671536 hydrochloride from Tocris? Please let us know.
Reviews for PF 04671536 hydrochloride
There are currently no reviews for this product. Be the first to review PF 04671536 hydrochloride and earn rewards!
Have you used PF 04671536 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.