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PF 04671536 hydrochloride
Biological Activity for PF 04671536 hydrochloride
PF 04671536 hydrochloride is a potent and selective PDE8B/8A inhibitor ( IC50 values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC50 values are >10 μM) and a range of other targets. Increases glucose-dependent insulin secretion from human pacreatic islet cells. Orally bioavailable.
Sold for research purposes under agreement from Pfizer Inc
Compound Libraries for PF 04671536 hydrochloride
Technical Data for PF 04671536 hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PF 04671536 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||7.66||20 with gentle warming|
Preparing Stock Solutions for PF 04671536 hydrochloride
The following data is based on the product molecular weight 382.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.61 mL||13.06 mL||26.12 mL|
|5 mM||0.52 mL||2.61 mL||5.22 mL|
|10 mM||0.26 mL||1.31 mL||2.61 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
Product Datasheets for PF 04671536 hydrochloride
References for PF 04671536 hydrochloride
References are publications that support the biological activity of the product.
DeNinno et al (2012) Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg.Med.Chem.Lett. 22 5721 PMID: 22858141
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Citations for PF 04671536 hydrochloride
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