Cilostamide

Pricing Availability   Qty
Description: PDE3 inhibitor
Alternative Names: OCP 3689
Chemical Name: N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
Purity: ≥97% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (1)

Biological Activity for Cilostamide

Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC50 values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC50 = 16.8 μM); antithrombotic.

Technical Data for Cilostamide

M. Wt 342.44
Formula C20H26N2O3
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 68550-75-4
PubChem ID 2753
InChI Key UIAYVIIHMORPSJ-UHFFFAOYSA-N
Smiles CN(C1CCCCC1)C(=O)CCCOC1=CC=C2NC(=O)C=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cilostamide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.85 20 with gentle warming

Preparing Stock Solutions for Cilostamide

The following data is based on the product molecular weight 342.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.6 mL 73.01 mL 146.01 mL
1 mM 2.92 mL 14.6 mL 29.2 mL
2 mM 1.46 mL 7.3 mL 14.6 mL
10 mM 0.29 mL 1.46 mL 2.92 mL

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Product Datasheets for Cilostamide

Certificate of Analysis / Product Datasheet
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References for Cilostamide

References are publications that support the biological activity of the product.

Hidaki et al (1979) Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation. J.Pharmacol.Exp.Ther. 211 26 PMID: 226672

Sudo et al (2000) Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem.Pharmacol. 59 347 PMID: 10644042

Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185


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Keywords: Cilostamide, Cilostamide supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, OCP3689, OCP, 3689, 0915, Tocris Bioscience

5 Citations for Cilostamide

Citations are publications that use Tocris products. Selected citations for Cilostamide include:

Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote. PLoS One 10 e0132884 PMID: 26222156

Ørstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. J Biol Chem 10 e0115547 PMID: 25738589

Brunet et al (2013) Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel. J Gen Physiol 141 85 PMID: 23250865

Hubert et al (2014) Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4. Br J Pharmacol 171 5361 PMID: 25048877


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Literature in this Area

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure