Cilostamide

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Cat.No. 0915 - Cilostamide | C20H26N2O3 | CAS No. 68550-75-4
Description: PDE3 inhibitor
Alternative Names: OCP 3689
Chemical Name: N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
Datasheet
Citations (4)
Literature

Biological Activity

Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC50 values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC50 = 16.8 μM); antithrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™.

Compound Libraries

Cilostamide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 342.44
Formula C20H26N2O3
Storage Store at RT
CAS Number 68550-75-4
PubChem ID 2753
InChI Key UIAYVIIHMORPSJ-UHFFFAOYSA-N
Smiles CN(C1CCCCC1)C(=O)CCCOC1=CC=C2NC(=O)C=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 342.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.6 mL 29.2 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hidaki et al (1979) Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation. J.Pharmacol.Exp.Ther. 211 26 PMID: 226672

Sudo et al (2000) Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem.Pharmacol. 59 347 PMID: 10644042

Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185 PMID:


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Keywords: Cilostamide, supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, OCP3689, OCP, 3689, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

4 Citations for Cilostamide

Citations are publications that use Tocris products. Selected citations for Cilostamide include:

Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. PLoS One 10 e0132884 PMID: 26222156

├śrstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. J Biol Chem 10 e0115547 PMID: 25738589

Brunet et al (2013) Increased intracellular magnesium attenuates ╬▓-adrenergic stimulation of the cardiac Ca(V)1.2 channel. J Gen Physiol 141 85 PMID: 23250865

Zhai et al (2012) ╬▓-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7 e47826 PMID: 23094097


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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pathways for Cilostamide

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