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Description: PDE inhibitor (non-selective)
Alternative Names: KC-404
Chemical Name: 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
Purity: ≥99% (HPLC)

Biological Activity for Ibudilast

Ibudilast is a phosphodiesterase inhibitor (IC50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Compound Libraries for Ibudilast

Ibudilast is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ibudilast

M. Wt 230.31
Formula C14H18N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 50847-11-5
PubChem ID 3671
Smiles CC(C)C(=O)C1=C2C=CC=CN2N=C1C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ibudilast

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.03 100
ethanol 23.03 100

Preparing Stock Solutions for Ibudilast

The following data is based on the product molecular weight 230.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.34 mL 21.71 mL 43.42 mL
5 mM 0.87 mL 4.34 mL 8.68 mL
10 mM 0.43 mL 2.17 mL 4.34 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

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References for Ibudilast

References are publications that support the biological activity of the product.

Kishi et al (2001) Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovasc.Drug Rev. 19 215 PMID: 11607039

Nishino et al (1983) KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis. Jpn.J.Pharmacol. 33 267 PMID: 6193303

Souness et al (1994) Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone. Br.J.Pharmacol. 111 1081 PMID: 8032594

If you know of a relevant reference for Ibudilast, please let us know.

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Keywords: Ibudilast, Ibudilast supplier, PDE, inhibitors, inhibits, non-selective, Phosphodiesterases, KC404, KC-404, 1694, Tocris Bioscience

Citations for Ibudilast

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