Ibudilast

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Cat.No. 1694 - Ibudilast | C14H18N2O | CAS No. 50847-11-5
Description: PDE inhibitor (non-selective)
Alternative Names: KC-404
Chemical Name: 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Phosphodiesterase inhibitor (IC50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Compound Libraries

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Technical Data

M. Wt 230.31
Formula C14H18N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 50847-11-5
PubChem ID 3671
InChI Key ZJVFLBOZORBYFE-UHFFFAOYSA-N
Smiles CC(C)C(=O)C1=C2C=CC=CN2N=C1C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.03 100
ethanol 23.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 230.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.34 mL 21.71 mL 43.42 mL
5 mM 0.87 mL 4.34 mL 8.68 mL
10 mM 0.43 mL 2.17 mL 4.34 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Kishi et al (2001) Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovasc.Drug Rev. 19 215 PMID: 11607039

Nishino et al (1983) KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis. Jpn.J.Pharmacol. 33 267 PMID: 6193303

Souness et al (1994) Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone. Br.J.Pharmacol. 111 1081 PMID: 8032594


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Keywords: Ibudilast, Ibudilast supplier, PDE, inhibitors, inhibits, non-selective, Phosphodiesterases, KC404, KC-404, 1694, Tocris Bioscience

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