PF 05180999

Pricing Availability   Qty
Description: Potent and selective PDE2A inhibitor
Chemical Name: 4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine
Purity: ≥98% (HPLC)

Biological Activity for PF 05180999

PF 05180999 is a potent and selective PDE2A inhibitor (IC50 = 1 nM). Exhibits 2000-fold selectivity for PDE2A over PDE10A. Brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 05180999

PF 05180999 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PF 05180999

M. Wt 414.39
Formula C19H17F3N8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1394033-54-5
PubChem ID 60143346
Smiles CC1=NC(C2=C(C3=NC=C(C(F)(F)F)C=C3)N(C)N=C2)=C4N1N=CN=C4N5CCC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 05180999

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.72 50
ethanol 20.72 50

Preparing Stock Solutions for PF 05180999

The following data is based on the product molecular weight 414.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.83 mL 24.13 mL 48.26 mL
2.5 mM 0.97 mL 4.83 mL 9.65 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
25 mM 0.1 mL 0.48 mL 0.97 mL

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References for PF 05180999

References are publications that support the biological activity of the product.

Mikami et al (2017) Discovery of orally bioavailable brain penetrating in vivo active phosphodiesterase 2a inhibitor series for the treatment of cognitive disorders. J.Med.Chem. 60 7658 PMID: 28759228

If you know of a relevant reference for PF 05180999, please let us know.

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Citations for PF 05180999

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