Potent and selective PDE2A inhibitor (IC50 = 1 nM). Exhibits 2000-fold selectivity for PDE2A over PDE10A. Brain penetrant.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 414.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.41 mL||12.07 mL||24.13 mL|
|5 mM||0.48 mL||2.41 mL||4.83 mL|
|10 mM||0.24 mL||1.21 mL||2.41 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the biological activity of the product.
Mikami et al (2017) Discovery of orally bioavailable brain penetrating in vivo active phosphodiesterase 2a inhibitor series for the treatment of cognitive disorders. J.Med.Chem. 60 7658 PMID: 28759228
If you know of a relevant reference for PF 05180999, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PF 05180999, PF 05180999 supplier, PF05180999, potent, selective, phosphodiesterase, PDE, 2a, inhibitors, inhibits, brain, penetrant, Phosphodiesterases, 6405, Tocris Bioscience
Citations for PF 05180999
Citations are publications that use Tocris products.
Currently there are no citations for PF 05180999. Do you know of a great paper that uses PF 05180999 from Tocris? Please let us know.
Reviews for PF 05180999
There are currently no reviews for this product. Be the first to review PF 05180999 and earn rewards!
Have you used PF 05180999?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.