Zaprinast

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Cat.No. 0947 - Zaprinast | C13H13N5O2 | CAS No. 37762-06-4
Description: GPR35 agonist
Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.

Compound Libraries

Zaprinast is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 271.28
Formula C13H13N5O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 37762-06-4
PubChem ID 5722
InChI Key REZGGXNDEMKIQB-UHFFFAOYSA-N
Smiles CCCOC1=C(C=CC=C1)C1=NC2=C(NN=N2)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 271.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.43 mL 36.86 mL
5 mM 0.74 mL 3.69 mL 7.37 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lugnier (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol.Ther. 109 366 PMID: 16102838

Soderling et al (1998) Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J.Biol.Chem. 273 15553 PMID: 9624145

Taniguchi et al (2006) Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 580 5003 PMID: 16934253

Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185 PMID:


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Keywords: Zaprinast, supplier, PDE5/6/9/11, inhibitors, inhibits, Phosphodiesterases, GPR35, Tocris Bioscience

2 Citations for Zaprinast

Citations are publications that use Tocris products. Selected citations for Zaprinast include:

Zerani et al (2004) Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea. J Endourol 183 279 PMID: 15531716

Polcari et al (2013) Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats. Proc Natl Acad Sci U S A 27 338 PMID: 22974473


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GPCR

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Pathways for Zaprinast

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