Zaprinast

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Cat.No. 0947 - Zaprinast | C13H13N5O2 | CAS No. 37762-06-4
Description: GPR35 agonist
Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.

Compound Libraries

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Technical Data

M. Wt 271.28
Formula C13H13N5O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 37762-06-4
PubChem ID 5722
InChI Key REZGGXNDEMKIQB-UHFFFAOYSA-N
Smiles CCCOC1=C(C=CC=C1)C1=NC2=C(NN=N2)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lugnier (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol.Ther. 109 366 PMID: 16102838

Soderling et al (1998) Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J.Biol.Chem. 273 15553 PMID: 9624145

Taniguchi et al (2006) Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 580 5003 PMID: 16934253

Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185


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Keywords: Zaprinast, Zaprinast supplier, PDE5/6/9/11, inhibitors, inhibits, Phosphodiesterases, GPR35, 0947, Tocris Bioscience

5 Citations for Zaprinast

Citations are publications that use Tocris products. Selected citations for Zaprinast include:

Rojewska (2018) Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model. Pharmacol Rep 71 139 PMID: 30550994

Robichaud et al (2002) Assessing the emetic potential of PDE4 inhibitors in rats. Br J Pharmacol 135 113 PMID: 11786486

MacKenzie et al (2014) The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35. Mol Pharmacol 85 91 PMID: 24113750

Zerani et al (2004) Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea. J Endourol 183 279 PMID: 15531716

Polcari et al (2013) Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats. Proc Natl Acad Sci U S A 27 338 PMID: 22974473


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Literature in this Area

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