Deltarasin

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Cat.No. 5424 - Deltarasin | C40H37N5O.3HCl | CAS No. 1440898-82-7
Description: High affinity PDEδ-KRAS interaction inhibitor
Chemical Name: 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity PDEδ-KRAS interaction inhibitor (Kd = 41 nM); binds to PDEδ. Reduces proliferation and induces cell death of KRAS-dependent Panc-Tu-1 and Capan-1 pancreatic cancer cells. Attenuates tumor growth of Panc-Tu-1 xenografts in mice.

Compound Libraries

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Technical Data

M. Wt 713.14
Formula C40H37N5O.3HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1440898-82-7
PubChem ID 91826089
InChI Key NCIOVAYUMQEQEU-VKZSUDIWSA-N
Smiles C12=CC=CC=C1N=C(C4=CC=C(OC[C@H]([C@H]8CCNCC8)N5C(C7=CC=CC=C7)=NC6=C5C=CC=C6)C=C4)N2CC3=CC=CC=C3.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 71.31 100
DMSO 71.31 100

Preparing Stock Solutions

The following data is based on the product molecular weight 713.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.4 mL 7.01 mL 14.02 mL
5 mM 0.28 mL 1.4 mL 2.8 mL
10 mM 0.14 mL 0.7 mL 1.4 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Zimmermann et al (2013) Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 497 638 PMID: 23698361

Zimmermann et al (2014) Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site. J.Med.Chem. 57 5435 PMID: 24884780


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Keywords: Deltarasin, Deltarasin supplier, high, affinity, PDEdelta, PDED, PDEδ, PDE6D, phosphodiesterases, KRAS, inhibitors, inhibits, GTPase, Phosphodiesterases, G, Proteins, (Small), 5424, Tocris Bioscience

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Literature in this Area

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