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Biological Activity for Gisadenafil besylate
Gisadenafil besylate is a potent PDE5 inhibitor (IC50 = 1.23 nM). Shows >100-fold selectivity for PDE5 over PDE6. Orally bioavailable.
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for Gisadenafil besylate
Technical Data for Gisadenafil besylate
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Gisadenafil besylate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Gisadenafil besylate
The following data is based on the product molecular weight 677.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.48 mL||7.38 mL||14.75 mL|
|5 mM||0.3 mL||1.48 mL||2.95 mL|
|10 mM||0.15 mL||0.74 mL||1.48 mL|
|50 mM||0.03 mL||0.15 mL||0.3 mL|
Product Datasheets for Gisadenafil besylate
References for Gisadenafil besylate
References are publications that support the biological activity of the product.
Hashim and Abrams (2010) Emerging drugs for the treatment of benign prostatic obstruction. Exp.Opin.Invest.Drugs 15 159 PMID: 20446824
Rawson et al (2012) The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics. Bioorg.Med.Chem. 20 498 PMID: 22100260
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Keywords: Gisadenafil besylate, Gisadenafil besylate supplier, pfizer, phosphodiesterases, inhibitors, inhibits, PDE5, UK369003, UK, 369003, Phosphodiesterases, 4165, Tocris Bioscience
1 Citation for Gisadenafil besylate
Citations are publications that use Tocris products. Selected citations for Gisadenafil besylate include:
Silva et al (2012) Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5. J Neuroinflammation 9 253 PMID: 23167821
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Literature in this Area
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