Gisadenafil besylate

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent PDE5 inhibitor; orally bioavailable
Alternative Names: UK 369003
Chemical Name: 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Gisadenafil besylate

Gisadenafil besylate is a potent PDE5 inhibitor (IC50 = 1.23 nM). Shows >100-fold selectivity for PDE5 over PDE6. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Gisadenafil besylate

Gisadenafil besylate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Gisadenafil besylate

M. Wt 677.79
Formula C23H33N7O5S.C6H6O3S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 334827-98-4
PubChem ID 23449797
InChI Key STFRDYSZKVPPQF-UHFFFAOYSA-N
Smiles O=S(C1=CN=C(OCC)C(C3=NC(C2=NN(CCOC)C(CC)=C2N3)=O)=C1)(N4CCN(CC)CC4)=O.O=S(C5=CC=CC=C5)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Gisadenafil besylate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.78 10
DMSO 67.78 100

Preparing Stock Solutions for Gisadenafil besylate

The following data is based on the product molecular weight 677.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.48 mL 7.38 mL 14.75 mL
5 mM 0.3 mL 1.48 mL 2.95 mL
10 mM 0.15 mL 0.74 mL 1.48 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Gisadenafil besylate

References for Gisadenafil besylate

References are publications that support the biological activity of the product.

Hashim and Abrams (2010) Emerging drugs for the treatment of benign prostatic obstruction. Exp.Opin.Invest.Drugs 15 159 PMID: 20446824

Rawson et al (2012) The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics. Bioorg.Med.Chem. 20 498 PMID: 22100260


If you know of a relevant reference for Gisadenafil besylate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phosphodiesterase Inhibitors

Keywords: Gisadenafil besylate, Gisadenafil besylate supplier, pfizer, phosphodiesterases, inhibitors, inhibits, PDE5, UK369003, UK, 369003, Phosphodiesterases, 4165, Tocris Bioscience

1 Citation for Gisadenafil besylate

Citations are publications that use Tocris products. Selected citations for Gisadenafil besylate include:

Silva et al (2012) Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5. J Neuroinflammation 9 253 PMID: 23167821


Do you know of a great paper that uses Gisadenafil besylate from Tocris? Please let us know.

Reviews for Gisadenafil besylate

There are currently no reviews for this product. Be the first to review Gisadenafil besylate and earn rewards!

Have you used Gisadenafil besylate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review