Gisadenafil besylate

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Cat.No. 4165 - Gisadenafil besylate | C23H33N7O5S.C6H6O3S | CAS No. 334827-98-4
Description: Potent PDE5 inhibitor; orally bioavailable
Alternative Names: UK 369003
Chemical Name: 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent PDE5 inhibitor (IC50 = 1.23 nM). Shows >100-fold selectivity for PDE5 over PDE6. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 677.79
Formula C23H33N7O5S.C6H6O3S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 334827-98-4
PubChem ID 23449797
InChI Key STFRDYSZKVPPQF-UHFFFAOYSA-N
Smiles O=S(C1=CN=C(OCC)C(C3=NC(C2=NN(CCOC)C(CC)=C2N3)=O)=C1)(N4CCN(CC)CC4)=O.O=S(C5=CC=CC=C5)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 67.78 100
water 6.78 10

Preparing Stock Solutions

The following data is based on the product molecular weight 677.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.48 mL 7.38 mL 14.75 mL
5 mM 0.3 mL 1.48 mL 2.95 mL
10 mM 0.15 mL 0.74 mL 1.48 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hashim and Abrams (2010) Emerging drugs for the treatment of benign prostatic obstruction. Exp.Opin.Invest.Drugs 15 159 PMID: 20446824

Rawson et al (2012) The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics. Bioorg.Med.Chem. 20 498 PMID: 22100260


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