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Description: Orally active PDE4 inhibitor
Chemical Name: (R)-5-(4-Methoxy-3-propoxyphenyl)-5-methyl-2-oxazolidinone
Purity: ≥98% (HPLC)

Biological Activity for Mesopram

Mesopram is an orally active phosphodiesterase (PDE) 4 inhibitor. Inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Triggers ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis in vivo.

Technical Data for Mesopram

M. Wt 265.31
Formula C14H19NO4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 189940-24-7
PubChem ID 449190
Smiles O=C1O[C@@](C2=CC(OCCC)=C(OC)C=C2)(C)CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mesopram

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.53 100
ethanol 26.53 100

Preparing Stock Solutions for Mesopram

The following data is based on the product molecular weight 265.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.69 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.88 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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References for Mesopram

References are publications that support the biological activity of the product.

Dinter et al (2000) The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents. J.Neuroimmunol. 108 136 PMID: 10900347

Loher et al (2003) The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J.Pharmacol.Exp.Ther. 305 549 PMID: 12606674

McKenna et al (2005) Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats. Endocrinology 146 208 PMID: 15448112

If you know of a relevant reference for Mesopram, please let us know.

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Keywords: Mesopram, Mesopram supplier, Orally, active, PDE4, inhibitors, inhibits, Phosphodiesterases, 3053, Tocris Bioscience

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