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Biological Activity for Mesopram
Mesopram is an orally active phosphodiesterase (PDE) 4 inhibitor. Inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Triggers ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis in vivo.
Technical Data for Mesopram
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Mesopram
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Mesopram
The following data is based on the product molecular weight 265.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.77 mL||18.85 mL||37.69 mL|
|5 mM||0.75 mL||3.77 mL||7.54 mL|
|10 mM||0.38 mL||1.88 mL||3.77 mL|
|50 mM||0.08 mL||0.38 mL||0.75 mL|
References for Mesopram
References are publications that support the biological activity of the product.
Dinter et al (2000) The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents. J.Neuroimmunol. 108 136 PMID: 10900347
Loher et al (2003) The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J.Pharmacol.Exp.Ther. 305 549 PMID: 12606674
McKenna et al (2005) Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats. Endocrinology 146 208 PMID: 15448112
If you know of a relevant reference for Mesopram, please let us know.
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Keywords: Mesopram, Mesopram supplier, Orally, active, PDE4, inhibitors, inhibits, Phosphodiesterases, 3053, Tocris Bioscience
Citations for Mesopram
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Literature in this Area
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