Mesopram

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Cat.No. 3053 - Mesopram | C14H19NO4 | CAS No. 189940-24-7
Description: Orally active PDE4 inhibitor
Chemical Name: (R)-5-(4-Methoxy-3-propoxyphenyl)-5-methyl-2-oxazolidinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Orally active phosphodiesterase (PDE) 4 inhibitor. Inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Triggers ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis in vivo.

Technical Data

M. Wt 265.31
Formula C14H19NO4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 189940-24-7
PubChem ID 449190
InChI Key PCCPERGCFKIYIS-AWEZNQCLSA-N
Smiles O=C1O[C@@](C2=CC(OCCC)=C(OC)C=C2)(C)CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.53 100
ethanol 26.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 265.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.69 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.88 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Dinter et al (2000) The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents. J.Neuroimmunol. 108 136 PMID: 10900347

Loher et al (2003) The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J.Pharmacol.Exp.Ther. 305 549 PMID: 12606674

McKenna et al (2005) Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats. Endocrinology 146 208 PMID: 15448112


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Keywords: Mesopram, supplier, Orally, active, PDE4, inhibitors, inhibits, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

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Asthma

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