Central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 194.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.15 mL||25.75 mL||51.5 mL|
|5 mM||1.03 mL||5.15 mL||10.3 mL|
|10 mM||0.51 mL||2.57 mL||5.15 mL|
|50 mM||0.1 mL||0.51 mL||1.03 mL|
References are publications that support the biological activity of the product.
Nehlig et al (1992) Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res.Brain Res.Rev. 17 139 PMID: 1356551
Fisone et al (2004) Caffeine as a psychomotor stimulant: mechanism of action. Cell.Mol.Life Sci. 61 857 PMID: 15095008
Chen et al (2008) Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J.Neuroinflammation 5 12 PMID: 18387175
If you know of a relevant reference for Caffeine, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Caffeine, Caffeine supplier, A1, A2B, antagonists, CNS, stimulant, cyclic, nucleotide, PDE, inhibitors, inhibits, non-selective, adenosines, receptors, phosphodiesterases, ryanodine, Non-selective, Adenosine, Phosphodiesterases, Ryanodine, Receptors, 2793, Tocris Bioscience
2 Citations for Caffeine
Citations are publications that use Tocris products. Selected citations for Caffeine include:
Okita et al (2015) Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells. PLoS One 10 e0139809 PMID: 26439264
Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. J Cell Sci 8 e66404 PMID: 23799098
Do you know of a great paper that uses Caffeine from Tocris? Please let us know.
Reviews for Caffeine
Average Rating: 5 (Based on 1 Review.)
Have you used Caffeine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Control or saxagliptin treated primary guinea pig cardiomyocytes were loaded with FURA-2AM (1 µM) and Pluronic F 127 (1%). Ca2+ transient decay tau evoked by caffeine (30 µM) is shown in the Image. Caffeine acts as a ryanodine receptor agonist and releases Ca2+ from sarcoplasmic reticulum into the cytosol.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.