cAMP

Cyclic adenosine monophosphate (cAMP) is an important second messenger that modifies the rate of some enzyme-catalyzed reactions in specific tissues, generating various metabolic responses. cAMP formation from ATP is catalyzed by adenylyl cyclase. Adenylyl cyclase is activated by G_s-protein-coupled receptors and inhibited by G_i-protein-coupled receptors.

cAMP degradation to 5'-AMP is catalyzed by increasing cytosolic Ca²⁺ levels and by phosphodiesterases. cAMP activates protein kinase A and Epac (exchange protein directly activated by cAMP) to mediate its intracellular effects. cAMP is involved in a variety of signaling pathways including those that regulate glycogen, glucose and lipid metabolism.

Dysregulation of cAMP has been implicated in tumorigenesis, diabetes and cardiovascular disease. More recently, it has been proposed that cAMP has a physiological role in prefrontal cortex functioning.

Literature for cAMP

Tocris offers the following scientific literature for cAMP to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

• Cancer Metabolism
• Epigenetics in Cancer
• Receptor Signaling
• Cell Cycle and DNA Damage Repair
• Angiogenesis
• Invasion and Metastasis

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