cAMP

Cyclic adenosine monophosphate (cAMP) is an important second messenger that modifies the rate of some enzyme-catalyzed reactions in specific tissues, generating various metabolic responses. cAMP formation from ATP is catalyzed by adenylyl cyclase (AC).

Products
Background
Literature
Cat No Product Name / Activity
1337 cAMPS-Rp, triethylammonium salt
cAMP antagonist
1333 cAMPS-Sp, triethylammonium salt
Cell-permeable cAMP analog
5255 6-Bnz-cAMP sodium salt
Cell permeable cAMP analog
1140 8-Bromo-cAMP, sodium salt
Cell-permeable cAMP analog
1141 Dibutyryl-cAMP, sodium salt
Cell-permeable cAMP analog
4853 8-pCPT-2-O-Me-cAMP-AM
Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)

Cyclic adenosine monophosphate (cAMP) is an important second messenger that modifies the rate of some enzyme-catalyzed reactions in specific tissues, generating various metabolic responses. cAMP formation from ATP is catalyzed by adenylyl cyclase. Adenylyl cyclase is activated by Gs-protein-coupled receptors and inhibited by Gi-protein-coupled receptors.

cAMP degradation to 5'-AMP is catalyzed by increasing cytosolic Ca2+ levels and by phosphodiesterases. cAMP activates protein kinase A and Epac (exchange protein directly activated by cAMP) to mediate its intracellular effects. cAMP is involved in a variety of signaling pathways including those that regulate glycogen, glucose and lipid metabolism.

Dysregulation of cAMP has been implicated in tumorigenesis, diabetes and cardiovascular disease. More recently, it has been proposed that cAMP has a physiological role in prefrontal cortex functioning.

Literature for cAMP

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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  • Epigenetics in Cancer
  • Receptor Signaling
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