Ro 20-1724

Pricing Availability   Qty
Description: PDE4 inhibitor
Chemical Name: 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Purity: ≥99% (HPLC)
Citations (3)

Biological Activity for Ro 20-1724

Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM).

Compound Libraries for Ro 20-1724

Ro 20-1724 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 20-1724

M. Wt 278.35
Formula C15H22N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 29925-17-5
PubChem ID 5087

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ro 20-1724

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 27.84 100
DMSO 27.84 100

Preparing Stock Solutions for Ro 20-1724

The following data is based on the product molecular weight 278.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.59 mL 17.96 mL 35.93 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.59 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets for Ro 20-1724

Certificate of Analysis / Product Datasheet
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References for Ro 20-1724

References are publications that support the biological activity of the product.

Nicholson et al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19 PMID: 1848733

Reeves et al (1987) The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Biochem.J. 241 535 PMID: 3036066

Soderling et al (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 95 8991 PMID: 9671792

If you know of a relevant reference for Ro 20-1724, please let us know.

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Keywords: Ro 20-1724, Ro 20-1724 supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, Ro20-1724, 0415, Tocris Bioscience

3 Citations for Ro 20-1724

Citations are publications that use Tocris products. Selected citations for Ro 20-1724 include:

Zhong et al (2012) Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. Neuropsychopharmacology 37 2377 PMID: 22713909

Peters et al (2007) Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs. J Biomol Screen 12 312 PMID: 17307886

Winger et al (2014) Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier. J Immunol 193 2427 PMID: 25063869

Do you know of a great paper that uses Ro 20-1724 from Tocris? Please let us know.

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