Ro 20-1724

Pricing Availability Delivery Time Qty
Cat.No. 0415 - Ro 20-1724 | C15H22N2O3 | CAS No. 29925-17-5
Description: PDE4 inhibitor
Chemical Name: 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). Also available as part of the Phosphodiesterase Inhibitor Tocriset™.

Compound Libraries

Ro 20-1724 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 278.35
Formula C15H22N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 29925-17-5
PubChem ID 5087
InChI Key PDMUULPVBYQBBK-UHFFFAOYSA-N
Smiles CCCCOC1=CC(CC2CNC(=O)N2)=CC=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.84 100
ethanol 27.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 278.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.59 mL 17.96 mL 35.93 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.59 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Nicholson et al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19 PMID: 1848733

Reeves et al (1987) The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Biochem.J. 241 535 PMID: 3036066

Soderling et al (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 95 8991 PMID: 9671792


If you know of a relevant reference for Ro 20-1724, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phosphodiesterase Inhibitors

Keywords: Ro 20-1724, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, Ro20-1724, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

1 Citation for Ro 20-1724

Citations are publications that use Tocris products. Selected citations for Ro 20-1724 include:

Winger et al (2014) Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier. J Immunol 193 2427 PMID: 25063869


Do you know of a great paper that uses Ro 20-1724 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pathways for Ro 20-1724

Protocols

TODO: Add Protocols