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Biological Activity for (R)-(-)-Rolipram
(R)-(-)-Rolipram is a more active enantiomer of the PDE4 inhibitor rolipram; 2-10-fold more potent than the S-(+) enantiomer.
Compound Libraries for (R)-(-)-Rolipram
Technical Data for (R)-(-)-Rolipram
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (R)-(-)-Rolipram
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for (R)-(-)-Rolipram
The following data is based on the product molecular weight 275.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.63 mL||18.16 mL||36.32 mL|
|5 mM||0.73 mL||3.63 mL||7.26 mL|
|10 mM||0.36 mL||1.82 mL||3.63 mL|
|50 mM||0.07 mL||0.36 mL||0.73 mL|
Product Datasheets for (R)-(-)-Rolipram
References for (R)-(-)-Rolipram
References are publications that support the biological activity of the product.
Ohsawa et al (1998) Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 77 147 PMID: 9681571
Owens et al (1997) Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 326 53 PMID: 9337850
Schneider et al (1986) Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 127 105 PMID: 3019721
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Keywords: (R)-(-)-Rolipram, (R)-(-)-Rolipram supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, 1349, Tocris Bioscience
1 Citation for (R)-(-)-Rolipram
Citations are publications that use Tocris products. Selected citations for (R)-(-)-Rolipram include:
Boomkamp et al (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. Br J Pharmacol 171 2385 PMID: 24467222
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Literature in this Area
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