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Description: PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)
Chemical Name: (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for (R)-(-)-Rolipram

(R)-(-)-Rolipram is a more active enantiomer of the PDE4 inhibitor rolipram; 2-10-fold more potent than the S-(+) enantiomer.

Racemate and S-enantiomer also available.

Compound Libraries for (R)-(-)-Rolipram

(R)-(-)-Rolipram is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (R)-(-)-Rolipram

M. Wt 275.35
Formula C16H21NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 85416-75-7
PubChem ID 448055
Smiles O=C1NC[C@@H](C2=CC(OC3CCCC3)=C(OC)C=C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-(-)-Rolipram

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 27.54 100
DMSO 27.54 100

Preparing Stock Solutions for (R)-(-)-Rolipram

The following data is based on the product molecular weight 275.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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Product Datasheets for (R)-(-)-Rolipram

Certificate of Analysis / Product Datasheet
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References for (R)-(-)-Rolipram

References are publications that support the biological activity of the product.

Ohsawa et al (1998) Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 77 147 PMID: 9681571

Owens et al (1997) Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 326 53 PMID: 9337850

Schneider et al (1986) Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 127 105 PMID: 3019721

If you know of a relevant reference for (R)-(-)-Rolipram, please let us know.

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Keywords: (R)-(-)-Rolipram, (R)-(-)-Rolipram supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, 1349, Tocris Bioscience

1 Citation for (R)-(-)-Rolipram

Citations are publications that use Tocris products. Selected citations for (R)-(-)-Rolipram include:

Boomkamp et al (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. Br J Pharmacol 171 2385 PMID: 24467222

Do you know of a great paper that uses (R)-(-)-Rolipram from Tocris? Please let us know.

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