Pricing Availability   Qty
Description: Potent and highly selective PDE5 inhibitor; orally bioavailable
Alternative Names: GF196960
Chemical Name: (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
Purity: ≥99% (HPLC)

Biological Activity for Tadalafil

Tadalafil is a potent and highly selective PDE5 inhibitor (IC50 = 5 nM). Exhibits > 2000-fold selectivity for PDE5 over PDEs 1,2,3 and 4 and 1000-fold selectivity over PDE6. Reduces blood pressure in hypertensive rats. Also delays tumor growth in a mouse model via inhibition of MDSC-mediated immunosuppression. Orally bioavailable.

Compound Libraries for Tadalafil

Tadalafil is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Tadalafil

M. Wt 389.4
Formula C22H19N3O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 171596-29-5
PubChem ID 110635
Smiles [H][C@]12CC3=C([C@@H](C4=CC5=C(C=C4)OCO5)N1C(CN(C2=O)C)=O)NC6=CC=CC=C36

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tadalafil

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.94 100

Preparing Stock Solutions for Tadalafil

The following data is based on the product molecular weight 389.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Tadalafil

References are publications that support the biological activity of the product.

Daugan et al (2003) The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J.Med.Chem. 46 4533 PMID: 14521415

Serafini et al (2006) Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J.Exp.Med. 203 2691 PMID: 17101732

If you know of a relevant reference for Tadalafil, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phosphodiesterase Inhibitors

Keywords: Tadalafil, Tadalafil supplier, phosphodiesterase, 5, PDE5, potent, highly, selective, inhibitors, inhibits, antihypertensive, anticancer, orally, bioavailable, GF196960, Phosphodiesterases, 6311, Tocris Bioscience

Citations for Tadalafil

Citations are publications that use Tocris products.

Currently there are no citations for Tadalafil. Do you know of a great paper that uses Tadalafil from Tocris? Please let us know.

Reviews for Tadalafil

There are currently no reviews for this product. Be the first to review Tadalafil and earn rewards!

Have you used Tadalafil?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review