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Furamidine dihydrochloride

Cat. No. 5202 Submit a Review Datasheet / COA / SDS
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Cat.No. 5202 - Furamidine dihydrochloride | C18H16N4O.2HCl | CAS No. 55368-40-6
Description: Selective PRMT1 inhibitor
Chemical Name: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines. Cell-permeable.

Compound Libraries

Furamidine dihydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 377.27
Formula C18H16N4O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 55368-40-6
PubChem ID 462428
InChI Key VXNYQUQHOUERTR-UHFFFAOYSA-N
Smiles NC(C(C=C3)=CC=C3C1=CC=C(C2=CC=C(C(N)=N)C=C2)O1)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.86 50
DMSO 18.86 50

Preparing Stock Solutions

The following data is based on the product molecular weight 377.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.3 mL 26.51 mL 53.01 mL
2.5 mM 1.06 mL 5.3 mL 10.6 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
25 mM 0.11 mL 0.53 mL 1.06 mL

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References

References are publications that support the biological activity of the product.

Yan et al (2014) Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J.Med.Chem. 57 2611 PMID: 24564570

If you know of a relevant reference for Furamidine dihydrochloride, please let us know.

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Keywords: Furamidine dihydrochloride, Furamidine dihydrochloride supplier, Selective, protein, arginine, methyltransferase, 1, PRMT1, inhibitors, inhibits, leukemia, coactivator-associated, Protein, Arginine, Methyltransferases, 5202, Tocris Bioscience

Citations for Furamidine dihydrochloride

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Literature in this Area

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Epigenetics Scientific Review

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