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Furamidine dihydrochloride

Cat. No. 5202 Submit a Review Datasheet / COA / SDS
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Cat.No. 5202 - Furamidine dihydrochloride | C18H16N4O.2HCl | CAS No. 55368-40-6
Description: Selective PRMT1 inhibitor
Chemical Name: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Furamidine dihydrochloride

Furamidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines. Cell-permeable.

Compound Libraries for Furamidine dihydrochloride

Furamidine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Furamidine dihydrochloride

M. Wt 377.27
Formula C18H16N4O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 55368-40-6
PubChem ID 462428
InChI Key VXNYQUQHOUERTR-UHFFFAOYSA-N
Smiles NC(C(C=C3)=CC=C3C1=CC=C(C2=CC=C(C(N)=N)C=C2)O1)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Furamidine dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.86 50
DMSO 18.86 50

Preparing Stock Solutions for Furamidine dihydrochloride

The following data is based on the product molecular weight 377.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.3 mL 26.51 mL 53.01 mL
2.5 mM 1.06 mL 5.3 mL 10.6 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
25 mM 0.11 mL 0.53 mL 1.06 mL

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Product Datasheets for Furamidine dihydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Furamidine dihydrochloride

References are publications that support the biological activity of the product.

Yan et al (2014) Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J.Med.Chem. 57 2611 PMID: 24564570

If you know of a relevant reference for Furamidine dihydrochloride, please let us know.

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Keywords: Furamidine dihydrochloride, Furamidine dihydrochloride supplier, Selective, protein, arginine, methyltransferase, 1, PRMT1, inhibitors, inhibits, leukemia, coactivator-associated, Protein, Arginine, Methyltransferases, 5202, Tocris Bioscience

Citations for Furamidine dihydrochloride

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Literature in this Area

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