Furamidine dihydrochloride

Pricing Availability   Qty
Description: Selective PRMT1 inhibitor
Chemical Name: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (1)

Biological Activity for Furamidine dihydrochloride

Furamidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits tyrosyl-DNA phosphodiesterase 1 (TDP-1) (IC50 = 1.2 μM). Inhibits cell proliferation in leukemia cell lines, suppresses neuroblastoma tumor growth, and reduces mis-splicing in in vitro and in vivo models of myotonic dystrophy type 1. Also shows dose-dependent inhibition of platelet aggregation (IC50 = 14.8 uM). Cell-permeable.

Compound Libraries for Furamidine dihydrochloride

Furamidine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Furamidine dihydrochloride

M. Wt 377.27
Formula C18H16N4O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 55368-40-6
PubChem ID 462428
InChI Key VXNYQUQHOUERTR-UHFFFAOYSA-N
Smiles NC(C(C=C3)=CC=C3C1=CC=C(C2=CC=C(C(N)=N)C=C2)O1)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Furamidine dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.86 50
DMSO 18.86 50

Preparing Stock Solutions for Furamidine dihydrochloride

The following data is based on the product molecular weight 377.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.3 mL 26.51 mL 53.01 mL
2.5 mM 1.06 mL 5.3 mL 10.6 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
25 mM 0.11 mL 0.53 mL 1.06 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Furamidine dihydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for Furamidine dihydrochloride

References are publications that support the biological activity of the product.

Yan et al (2014) Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J.Med.Chem. 57 2611 PMID: 24564570

Jenquin et al (2018) Furamidine rescues myotonic dystrophy type I associated mis-splicing through multiple mechanisms. ACS Chem.Biol. 13 2708 PMID: 30118588

Hua et al (2020) PRMT1 promotes neuroblastoma cell survival through ATF5. Oncogenesis 9 50 PMID: 32415090

Marsden et al (2021) Inhibition of arginine methylation impairs platelet function. ACS Pharmacol.Transl.Sci. 4 1567 PMID: 34661075


If you know of a relevant reference for Furamidine dihydrochloride, please let us know.

View Related Products by Product Action

View all Protein Arginine Methyltransferase Inhibitors

Keywords: Furamidine dihydrochloride, Furamidine dihydrochloride supplier, Selective, protein, arginine, methyltransferase, 1, PRMT1, inhibitors, inhibits, leukemia, coactivator-associated, tdp1, tyrosyl, DNA, topoisomerase, Protein, Arginine, Methyltransferases, Phosphodiesterases, 5202, Tocris Bioscience

5 Citations for Furamidine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Furamidine dihydrochloride include:

Samuel et al (2018) Inhibiting Arginine Methylation as a Tool to Investigate Cross-Talk with Methylation and Acetylation Post-Translational Modifications in a Glioblastoma Cell Line. Proteomes 6 44 PMID: 30347783

Min-Jung et al (2020) TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes. FEBS Lett 594 2923-2930 PMID: 32767856

Marsden et al (2021) Inhibition of Arginine Methylation Impairs Platelet Function. ACS Pharmacol.Transl.Sci 4 1567 PMID: 34661075

Jer-Yen et al (2022) PRMT1 is an important factor for medulloblastoma cell proliferation and survival. Biochem Biophys Rep 32 101364 PMID: 36237442


Do you know of a great paper that uses Furamidine dihydrochloride from Tocris? Please let us know.

Reviews for Furamidine dihydrochloride

There are currently no reviews for this product. Be the first to review Furamidine dihydrochloride and earn rewards!

Have you used Furamidine dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.