Home / Pharmacology / Enzymes / Phosphodiesterases / Phosphodiesterase Inhibitors / BRL 50481

BRL 50481

Cat. No. 2237 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective PDE7 inhibitor
Chemical Name: N,N,2-Trimethyl-5-nitro-benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BRL 50481

BRL 50481 is a selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries for BRL 50481

BRL 50481 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BRL 50481

M. Wt 244.26
Formula C9H12N2O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 433695-36-4
PubChem ID 2921148
InChI Key IFIUFCJFLGCQPH-UHFFFAOYSA-N
Smiles CN(C)S(=O)(=O)C1=C(C)C=CC(=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BRL 50481

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 24.43 100
DMSO 24.43 100

Preparing Stock Solutions for BRL 50481

The following data is based on the product molecular weight 244.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.94 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for BRL 50481

References are publications that support the biological activity of the product.

Smith et al (2004) Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol.Pharmacol. 66 1679 PMID: 15371556

If you know of a relevant reference for BRL 50481, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phosphodiesterase Inhibitors

Keywords: BRL 50481, BRL 50481 supplier, Selective, PDE7, inhibitors, inhibits, Phosphodiesterases, BRL50481, GlaxoSmithKline, GSK, 2237, Tocris Bioscience

3 Citations for BRL 50481

Citations are publications that use Tocris products. Selected citations for BRL 50481 include:

Zhai et al (2012) β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7 e47826 PMID: 23094097

Meyers et al (2009) Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors. J Immunol 182 5400 PMID: 19380787

Morales-Garcia et al (2011) Phosphodiesterase 7 inhibition preserves DArgic neurons in cellular and rodent models of Parkinson disease. J Biol Chem 6 e17240 PMID: 21390306

Do you know of a great paper that uses BRL 50481 from Tocris? Please let us know.

Reviews for BRL 50481

There are currently no reviews for this product. Be the first to review BRL 50481 and earn rewards!

Have you used BRL 50481?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure