Mitosis is a highly complex and regulated sequence of events that occurs exclusively in eukaryotic cells and produces two identical daughter cells from a single parent cell. It is split into five phases; prophase, prometaphase, metaphase, anaphase and telophase.

Literature (2)
Cat. No. Product Name / Activity
6923 AMZ 30
Induces shortening of mitotic spindles and mitotic arrest; PME-1 inhibitor
5747 Apcin
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
5736 Aphidicolin
DNA polymerase α, δ and ε inhibitor; antimitotic
7549 BAY 1816032
Potent and selective BUB1 kinase inhibitor
5399 BTB1
Selective and ATP-competitive Kif18A inhibitor
5687 Centrinone
High affinity and selective PLK4 inhibitor
5690 Centrinone B
High affinity and selective PLK4 inhibitor
1364 Colchicine
Inhibitor of tubulin
5130 CTCE 9908
CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells
3116 Cyclapolin 9
Selective, ATP-competitive PLK1 inhibitor
5261 Dimethylenastron
Inhibitor of mitotic motor kinesin Eg5; antimitotic
1774 Dynamin inhibitory peptide
Dynamin inhibitor
1775 Dynamin inhibitory peptide, myristoylated
Cell-permeable dynamin inhibitor
2897 Dynasore
Non-competitive dynamin inhibitor
2226 Flutax 1
Fluorescent taxol derivative; binds microtubules
6254 Flutax 2
Green fluorescent taxol derivative; binds microtubules
2977 GW 843682X
Selective inhibitor of PLK1 and PLK3
3728 Indibulin
Microtubule destabilizer
3982 Mdivi 1
Selective dynamin inhibitor; attentuates mitochondrial division
1305 Monastrol
Selective inhibitor of mitotic kinesin Eg5
1228 Nocodazole
Microtubule inhibitor
5403 TAK 960 hydrochloride
Potent and selective PLK1 inhibitor
1097 Taxol
Promotes assembly and inhibits disassembly of microtubules
4459 TC-S 7005
Potent and selective PLK2 inhibitor
2191 S-Trityl-L-cysteine
Potent, selective inhibitor of mitotic kinesin Eg5
1256 Vinblastine sulfate
Disrupts microtubules
1257 Vincristine sulfate
Disrupts microtubules
1232 Wortmannin
Potent inhibitor of PLK1. Also inhibitor of PI 3-kinase
2458 ZM 447439
Inhibits Aurora kinase B

Mitosis is a highly complex and regulated sequence of events that occurs exclusively in eukaryotic cells and produces two identical daughter cells from a single parent cell.

Mitosis is split into five phases:

  1. Prophase - Chromatin condenses to form chromosomes. Centrosomes begin to migrate to opposite poles of the cell.
  2. Prometaphase - The nuclear envelope breaks down and centrosomes are situated at opposite poles of the cell. Sister chromatids attach to the microtubule spindles.
  3. Metaphase - Chromosomes align along the equatorial plane.
  4. Anaphase - The sister chromatids separate and are pulled to opposite poles of the cell along the microtubule spindles.
  5. Telophase - A new nuclear envelope forms around each set of sister chromatids. The chromatids decondense to chromatin and mitotic spindles start to break down.

Cytokinesis is a separate process that follows mitosis in order to complete cell division. It involves cleavage of the cytoplasm due to contraction of actin microfilaments that form a ring around the equator of the cell. This results in the formation of two daughter cells, each identical to the parent, that enter interphase at G0.

Literature for Mitosis

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.