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Biological Activity for Apcin
Apcin is a Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.
Technical Data for Apcin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Apcin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Apcin
The following data is based on the product molecular weight 438.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.28 mL||11.4 mL||22.8 mL|
|5 mM||0.46 mL||2.28 mL||4.56 mL|
|10 mM||0.23 mL||1.14 mL||2.28 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References for Apcin
References are publications that support the biological activity of the product.
Sackton et al (2014) Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature 514 646 PMID: 25156254
Wang et al (2015) Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol.Ther. 151 141 PMID: 25850036
If you know of a relevant reference for Apcin, please let us know.
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Keywords: Apcin, Apcin supplier, Cdc20, inhibitors, inhibits, APC, anaphase-promoting, complex, ubiquitin, ubiquitination, ligases, E3, Ubiquitin, Ligases, Mitosis, 5747, Tocris Bioscience
5 Citations for Apcin
Citations are publications that use Tocris products. Selected citations for Apcin include:
Shabaz et al (2020) Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit. Elife 9 PMID: 32869743
Venturina et al (2023) AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation. Life Sci Alliance 6 PMID: 36797043
Lin et al (2023) Kinetochore deterioration concommitant with centromere weakening during aging in mouse oocyte meiosis-I. FASEB J 37 e22922 PMID: 37078553
Afonso et al (2019) Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk. Elife 8 PMID: 31424385
Greg et al (2019) Tetraploidy causes chromosomal instability in acentriolar mouse embryos. Nat Commun 10 4834 PMID: 31645568
Do you know of a great paper that uses Apcin from Tocris? Please let us know.
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Literature in this Area
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