Pricing Availability Delivery Time Qty
Cat.No. 5747 - Apcin | C13H14Cl3N7O4 | CAS No. 300815-04-7
Description: Cdc20 inhibitor; inhibits Cdc20-substrate interaction
Chemical Name: 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide
Purity: ≥98% (HPLC)

Biological Activity

Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.

Technical Data

M. Wt 438.65
Formula C13H14Cl3N7O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 300815-04-7
PubChem ID 2830389
Smiles CC1=NC=C([N+]([O-])=O)N1CCOC(NC(C(Cl)(Cl)Cl)NC2=NC=CC=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.87 100
ethanol 2.19 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 438.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.4 mL 22.8 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Sackton et al (2014) Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature 514 646 PMID: 25156254

Wang et al (2015) Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol.Ther. 151 141 PMID: 25850036

If you know of a relevant reference for Apcin, please let us know.

View Related Products by Product Action

View all Ubiquitin E3 Ligase Inhibitors

Keywords: Apcin, supplier, Cdc20, inhibitors, inhibits, APC, anaphase-promoting, complex, ubiquitin, ubiquitination, ligases, E3, Ubiquitin, E3, Ligases, Mitosis, Ubiquitin, E3, Ligases, Tocris Bioscience

Citations for Apcin

Citations are publications that use Tocris products.

Currently there are no citations for Apcin. Do you know of a great paper that uses Apcin from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Apcin


TODO: Add Protocols