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Description: Cdc20 inhibitor; inhibits Cdc20-substrate interaction
Chemical Name: 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide
Purity: ≥98% (HPLC)
Citations (5)
Literature (3)

Biological Activity for Apcin

Apcin is a Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.

Technical Data for Apcin

M. Wt 438.65
Formula C13H14Cl3N7O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 300815-04-7
PubChem ID 2830389
Smiles CC1=NC=C([N+]([O-])=O)N1CCOC(NC(C(Cl)(Cl)Cl)NC2=NC=CC=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Apcin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.87 100

Preparing Stock Solutions for Apcin

The following data is based on the product molecular weight 438.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.4 mL 22.8 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for Apcin

References are publications that support the biological activity of the product.

Sackton et al (2014) Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature 514 646 PMID: 25156254

Wang et al (2015) Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol.Ther. 151 141 PMID: 25850036

If you know of a relevant reference for Apcin, please let us know.

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Keywords: Apcin, Apcin supplier, Cdc20, inhibitors, inhibits, APC, anaphase-promoting, complex, ubiquitin, ubiquitination, ligases, E3, Ubiquitin, Ligases, Mitosis, 5747, Tocris Bioscience

5 Citations for Apcin

Citations are publications that use Tocris products. Selected citations for Apcin include:

Shabaz et al (2020) Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit. Elife 9 PMID: 32869743

Afonso et al (2019) Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk. Elife 8 PMID: 31424385

Greg et al (2019) Tetraploidy causes chromosomal instability in acentriolar mouse embryos. Nat Commun 10 4834 PMID: 31645568

Venturina et al (2023) AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation. Life Sci Alliance 6 PMID: 36797043

Do you know of a great paper that uses Apcin from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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