CTCE 9908

Pricing Availability Delivery Time Qty
Cat.No. 5130 - CTCE 9908 | Lys-Gly-Val-Ser-Leu-Ser-Tyr-Arg-Lys-NH2 Lys-Gly-Val-Ser-Leu-Ser-Tyr-Arg* | CAS No. 1030384-98-5
Description: CXCR4 antagonist; antitumor
Datasheet
Citations
Literature

Biological Activity

CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol (Cat. No. 1097). Enhances the efficacy of docetaxel (Cat. No. 4056) in a mouse model.

Technical Data

M. Wt 1927.27
Formula C86H147N27O23
Sequence KGVSLSYRK KGVSLSYR*

(Modifications: Amide bridge = 9-8*, Lys-9 = C-terminal amide)

Storage Store at -20°C
CAS Number 1030384-98-5
PubChem ID 90489012
InChI Key VUYRSKROGTWHDC-ICWZLGNASA-N
Smiles [H]N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N[H])CCCCN)C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility

Preparing Stock Solutions

The following data is based on the product molecular weight 1927.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.52 mL 2.59 mL 5.19 mL
5 mM 0.1 mL 0.52 mL 1.04 mL
10 mM 0.05 mL 0.26 mL 0.52 mL
50 mM 0.01 mL 0.05 mL 0.1 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kwong et al (2009) An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol.Cancer Ther. 8 1893 PMID: 19567818

Hassan et al (2011) CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int.J.Cancer. 129 225 PMID: 20830712

Faber et al (2007) The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J.Biomed.Biotechnol. 2007 26065 PMID: 17541466


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Keywords: CTCE9908 CXCR4 receptor chemokines antagonists ovarian cancer mitotic catastrophe mitosis Chemokine CXC Receptors

Citations for CTCE 9908

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Literature in this Area

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Pathways for CTCE 9908

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