CTCE 9908

Pricing Availability   Qty
Description: CXCR4 antagonist; antitumor
Purity: ≥95% (HPLC)
Citations (1)
Literature (1)

Biological Activity for CTCE 9908

CTCE 9908 is a CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol (Cat. No. 1097). Enhances the efficacy of docetaxel (Cat. No. 4056) in a mouse model.

Technical Data for CTCE 9908

M. Wt 1927.27
Formula C86H147N27O23

(Modifications: Amide bridge = 9-8*, Lys-9 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1030384-98-5
PubChem ID 90489012
Smiles [H]N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N[H])CCCCN)C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CTCE 9908

Solubility Soluble to 2 mg/ml in water

Product Datasheets for CTCE 9908

Certificate of Analysis / Product Datasheet
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References for CTCE 9908

References are publications that support the biological activity of the product.

Kwong et al (2009) An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol.Cancer Ther. 8 1893 PMID: 19567818

Hassan et al (2011) CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or doce. in a transgenic mouse model. Int.J.Cancer. 129 225 PMID: 20830712

Faber et al (2007) The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J.Biomed.Biotechnol. 2007 26065 PMID: 17541466

If you know of a relevant reference for CTCE 9908, please let us know.

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Keywords: CTCE 9908, CTCE 9908 supplier, CTCE9908, CXCR4, receptor, chemokines, antagonists, ovarian, cancer, mitotic, catastrophe, mitosis, Mitosis, Chemokine, CXC, Receptors, 5130, Tocris Bioscience

1 Citation for CTCE 9908

Citations are publications that use Tocris products. Selected citations for CTCE 9908 include:

Ludger et al (2020) Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands. Sci Rep 10 16036 PMID: 32994431

Do you know of a great paper that uses CTCE 9908 from Tocris? Please let us know.

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Literature in this Area

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Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.