Vincristine sulfate

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Cat.No. 1257 - Vincristine sulfate | C46H56N4O10.H2SO4 | CAS No. 2068-78-2
Description: Disrupts microtubules
Chemical Name: 22-Oxovincaleukoblastine
Purity: ≥96% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.

Technical Data

M. Wt 923.04
Formula C46H56N4O10.H2SO4
Storage Store at -20°C
Purity ≥96% (HPLC)
CAS Number 2068-78-2
PubChem ID 249332
InChI Key AQTQHPDCURKLKT-JKDPCDLQSA-N
Smiles OS(O)(=O)=O.[H][C@@]23N(C=O)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 923.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.08 mL 5.42 mL 10.83 mL
5 mM 0.22 mL 1.08 mL 2.17 mL
10 mM 0.11 mL 0.54 mL 1.08 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741 PMID: 3986806

Takano et al (1993) Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol.Res.Pract. 189 197 PMID: 8321748

Wang et al (1999) The effect of antimicrotubule agents on signal transduction pathways of apoptosis. Cancer Chemother.Pharmacol. 44 355 PMID: 10501907


If you know of a relevant reference for Vincristine sulfate, please let us know.

Keywords: Vincristine sulfate, supplier, Disrupts, microtubules, Tau, Tubulin, Mitosis, chemotherapeutics, Microtubules, Tocris Bioscience

4 Citations for Vincristine sulfate

Citations are publications that use Tocris products. Selected citations for Vincristine sulfate include:

Heinemann et al (2011) Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer. Sci Rep 11 221 PMID: 21645351

Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007

Goldman et al (2015) Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition. Nat Commun 6 6139 PMID: 25669750

Knutson et al (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One 9 e111840 PMID: 25493630


Do you know of a great paper that uses Vincristine sulfate from Tocris? If so please let us know.

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Literature in this Area

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Pathways for Vincristine sulfate

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