Vincristine sulfate

Pricing Availability   Qty
Cat.No. 1257 - Vincristine sulfate | C46H56N4O10.H2SO4 | CAS No. 2068-78-2
Description: Disrupts microtubules
Chemical Name: 22-Oxovincaleukoblastine
Purity: ≥96% (HPLC)
Datasheet
Citations (9)
Reviews (1)
Literature (2)

Biological Activity

Anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.

Technical Data

M. Wt 923.04
Formula C46H56N4O10.H2SO4
Storage Store at -20°C
Purity ≥96% (HPLC)
CAS Number 2068-78-2
PubChem ID 249332
InChI Key AQTQHPDCURKLKT-JKDPCDLQSA-N
Smiles OS(O)(=O)=O.[H][C@@]23N(C=O)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 923.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.08 mL 5.42 mL 10.83 mL
5 mM 0.22 mL 1.08 mL 2.17 mL
10 mM 0.11 mL 0.54 mL 1.08 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741 PMID: 3986806

Takano et al (1993) Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol.Res.Pract. 189 197 PMID: 8321748

Wang et al (1999) The effect of antimicrotubule agents on signal transduction pathways of apoptosis. Cancer Chemother.Pharmacol. 44 355 PMID: 10501907


If you know of a relevant reference for Vincristine sulfate, please let us know.

Keywords: Vincristine sulfate, Vincristine sulfate supplier, Disrupts, microtubules, Tau, Tubulin, Mitosis, chemotherapeutics, Microtubules, 1257, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Vincristine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

9 Citations for Vincristine sulfate

Citations are publications that use Tocris products. Selected citations for Vincristine sulfate include:

Goldman et al (2015) Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition. Nat Commun 6 6139 PMID: 25669750

Knutson et al (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One 9 e111840 PMID: 25493630

Mabe et al (2018) Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. J Clin Invest 128 4413 PMID: 30148456

Stojcheva et al (2016) MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM. Oncotarget 7 12937 PMID: 26887050


Do you know of a great paper that uses Vincristine sulfate from Tocris? Please let us know.

Reviews for Vincristine sulfate

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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma.
By Anonymous on 11/17/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Human epidermal carcinoma cell line

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007
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