Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of α- and β-tubulin polymers. Each microtubule is polarized; at one end α-subunits are exposed (-) and at the other, β-subunits are exposed (+).
Cat. No. | Product Name / Activity |
---|---|
4138 | ABT 751 |
Inhibitor of microtubule polymerization; antimitotic and antitumor | |
6043 | AMBMP hydrochloride |
Tubulin polymerization inhibitor; also Wnt canonical signaling activator | |
2186 | CMPD-1 |
Tubulin polymerization inhibitor; also selective inhibitor of p38α-mediated MK2a phosphorylation | |
1364 | Colchicine |
Inhibitor of tubulin | |
6273 | CRT 0105950 |
Disrupts microtrubule organization; potent LIMK1/2 inhibitor | |
1643 | D-64131 |
Tubulin polymerization inhibitor. Antitumor in vivo | |
6779 | Davunetide |
Highly potent active component of ADNP; increases tau-microtubule interactions | |
4056 | Docetaxel |
Microtubule stabilizer | |
3375 | Dolastatin 10 trifluoroacetate |
Tubulin polymerization inhibitor | |
3502 | Epothilone B |
Microtubule stabilization agent; promotes tubulin polymerization | |
2226 | Flutax 1 |
Fluorescent taxol derivative; microtubule stain | |
6254 | Flutax 2 |
Green fluorescent taxol derivative; binds microtubules | |
5075 | Harmine |
Potent and selective Dyrk1A inhibitor; inhibits tau phosphorylation | |
7303 | iHAP1 New |
Inhibits tubulin polymerization in vitro; allosteric activator of PP2A | |
3728 | Indibulin |
Microtubule destabilizer | |
4997 | INDY |
Dyrk1A/B inhibitor; inhibits abberant tau phosphorylation | |
4007 | Laulimalide |
Microtubule stabilzing agent | |
3213 | Methylene Blue |
Inhibitor of tau aggregation | |
5683 | MMAE |
Potent dolastatin 10 analog; antitumor | |
5231 | MPC 6827 hydrochloride |
Inhibitor of microtubule polymerization; antimitotic and antitumor | |
1228 | Nocodazole |
Microtubule inhibitor | |
1697 | Noscapine hydrochloride |
Tubulin inhibitor; induces apoptosis | |
6726 | T-peptide |
Cytotoxic Tau peptide; cell permeable | |
1097 | Taxol |
Promotes assembly and inhibits disassembly of microtubules | |
4286 | UA 62784 |
Inhibits microtubule polymerization | |
1256 | Vinblastine sulfate |
Disrupts microtubules | |
1257 | Vincristine sulfate |
Disrupts microtubules | |
3401 | Vinorelbine ditartrate |
Selective mitotic microtubule antagonist |
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of α- and β-tubulin polymers. Each microtubule is polarized, at one end α-subunits are exposed (-) and at the other β-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move along, a process that requires motor proteins.
The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis. Due to this central role in cell division, microtubules are of interest as a therapeutic target in cancer research. Both inhibition of microtubule polymerization and stabilization of the microtubules block cell division, and molecules which affect microtubule assembly are therefore of potential use as anticancer agents.
Tocris offers the following scientific literature for Microtubules to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
Tubulin α1A | Human | TUBA1A | NM_006009 | Q71U36 |
Mouse | Tuba1a | NM_011653 | P68369 | |
Rat | Tuba1a | NM_022298 | P68370 | |
Tubulin α1B | Human | TUBA1B | NM_006082 | P68363 |
Mouse | Tuba1b | NM_011654 | P05213 | |
Rat | Tuba1b | NM_001044270 | Q6P9V9 | |
Tubulin α1C | Human | TUBA1C | NM_032704 | Q9BQE3 |
Mouse | Tuba1c | NM_009448 | P68373 | |
Rat | Tuba1c | NM_001011995 | Q6AYZ1 | |
Tubulin α3A | Mouse | Tuba3a | NM_009446 | P05214 |
Rat | Tuba3a | NM_001040008 | Q68FR8 | |
Tubulin α3B | Mouse | Tuba3b | NM_009449 | P05214 |
Rat | Tuba3b | NM_001024336 | Q68FR8 | |
Tubulin α3C | Human | TUBA3C | NM_006001 | Q13748 |
Tubulin α3D | Human | TUBA3D | NM_080386 | Q13748 |
Tubulin α3E | Human | TUBA3E | NM_207312 | Q6PEY2 |
Tubulin α4A | Human | TUBA4A | NM_006000 | P68366 |
Mouse | Tuba4a | NM_009447 | P68368 | |
Rat | Tuba4a | NM_001007004 | Q5XIF6 | |
Tubulin α8 | Human | TUBA8 | NM_018943 | Q9NY65 |
Mouse | Tuba8 | NM_017379 | Q9JJZ2 | |
Rat | Tuba8 | NM_001024339 | Q6AY56 | |
Tubulin β | Human | TUBB | NM_178014 | P07437 |
Mouse | Tubb5 | NM_011655 | P99024 | |
Rat | Tubb5 | NM_173102 | P69897 | |
Tubulin β1 | Human | TUBB1 | NM_030773 | Q9H4B7 |
Mouse | Tubb1 | NM_001080971 | NP_001074440 | |
Tubulin β2A | Human | TUBB2A | NM_001069 | Q13885 |
Mouse | Tubb2a | NM_009450 | Q7TMM9 | |
Rat | Tubb2a | NM_001109119 | P85108 | |
Tubulin β2B | Human | TUBB2B | NM_178012 | Q9BVA1 |
Mouse | Tubb2b | NM_023716 | Q9CWF2 | |
Rat | Tubb2b | NM_001013886 | Q3KRE8 | |
Tubulin β2C | Human | TUBB2C | NM_006088 | P68371 |
Mouse | Tubb2c | NM_146116 | P68372 | |
Rat | Tubb2c | NM_199094 | Q6P9T8 | |
Tubulin β3 | Human | TUBB3 | NM_006086 | Q13509 |
Mouse | Tubb3 | NM_023279 | Q9ERD7 | |
Rat | Tubb3 | NM_139254 | Q8K5B7 | |
Tubulin β4 | Human | TUBB4 | NM_006087 | P04350 |
Mouse | Tubb4 | NM_009451 | Q9D6F9 | |
Rat | Tubb4 | NM_080882 | Q8VIP3 | |
Tubulin β6 | Human | TUBB6 | NM_032525 | Q9BUF5 |
Mouse | Tubb6 | NM_026473 | Q922F4 | |
Rat | Tubb6 | NM_001025675 | Q4QQV0 |