Microtubules

Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of α- and β-tubulin polymers. Each microtubule is polarized; at one end α-subunits are exposed (-) and at the other, β-subunits are exposed (+).

Products
Background
Literature
Gene Data

Other

Cat No Product Name / Activity
4138 ABT 751
Inhibitor of microtubule polymerization; antimitotic and antitumor
6043 AMBMP hydrochloride
Tubulin polymerization inhibitor; also Wnt canonical signaling activator
2186 CMPD-1
Tubulin polymerization inhibitor; also selective inhibitor of p38α-mediated MK2a phosphorylation
1364 Colchicine
Inhibitor of tubulin
1495 Combretastatin A4
Tubulin polymerization inhibitor. Antitumor, antiangiogenic and antimetastatic
1643 D-64131
Tubulin polymerization inhibitor. Antitumor in vivo
4056 Docetaxel
Microtubule stabilizer
3375 Dolastatin 10 trifluoroacetate
Tubulin polymerization inhibitor
3502 Epothilone B
Microtubule stabilization agent; promotes tubulin polymerization
2226 Flutax 1
Fluorescent taxol derivative
5075 Harmine
Potent and selective Dyrk1A inhibitor; inhibits tau phosphorylation
3728 Indibulin
Microtubule destabilizer
4997 INDY
Dyrk1A/B inhibitor; inhibits abberant tau phosphorylation
3213 Methylene Blue
Inhibitor of tau aggregation
5683 MMAE
Potent dolastatin 10 analog; antitumor
5231 MPC 6827 hydrochloride
Inhibitor of microtubule polymerization; antimitotic and antitumor
1228 Nocodazole
Microtubule inhibitor
1697 Noscapine hydrochloride
Tubulin inhibitor; induces apoptosis
1097 Taxol
Promotes assembly and inhibits disassembly of microtubules
4286 UA 62784
Inhibits microtubule polymerization
1256 Vinblastine sulfate
Disrupts microtubules
1257 Vincristine sulfate
Disrupts microtubules
3401 Vinorelbine ditartrate
Selective mitotic microtubule antagonist
3101 XRP44X
Microtubule depolymerization agent. Also Ras-Net pathway inhibitor

Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of α- and β-tubulin polymers. Each microtubule is polarized, at one end α-subunits are exposed (-) and at the other β-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move along, a process that requires motor proteins.

The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis. Due to this central role in cell division, microtubules are of interest as a therapeutic target in cancer research. Both inhibition of microtubule polymerization and stabilization of the microtubules block cell division, and molecules which affect microtubule assembly are therefore of potential use as anticancer agents.

Literature for Microtubules

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Microtubule Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Tubulin α1A Human TUBA1A NM_006009 Q71U36
Mouse Tuba1a NM_011653 P68369
Rat Tuba1a NM_022298 P68370
Tubulin α1B Human TUBA1B NM_006082 P68363
Mouse Tuba1b NM_011654 P05213
Rat Tuba1b NM_001044270 Q6P9V9
Tubulin α1C Human TUBA1C NM_032704 Q9BQE3
Mouse Tuba1c NM_009448 P68373
Rat Tuba1c NM_001011995 Q6AYZ1
Tubulin α3A Mouse Tuba3a NM_009446 P05214
Rat Tuba3a NM_001040008 Q68FR8
Tubulin α3B Mouse Tuba3b NM_009449 P05214
Rat Tuba3b NM_001024336 Q68FR8
Tubulin α3C Human TUBA3C NM_006001 Q13748
Tubulin α3D Human TUBA3D NM_080386 Q13748
Tubulin α3E Human TUBA3E NM_207312 Q6PEY2
Tubulin α4A Human TUBA4A NM_006000 P68366
Mouse Tuba4a NM_009447 P68368
Rat Tuba4a NM_001007004 Q5XIF6
Tubulin α8 Human TUBA8 NM_018943 Q9NY65
Mouse Tuba8 NM_017379 Q9JJZ2
Rat Tuba8 NM_001024339 Q6AY56
Tubulin β Human TUBB NM_178014 P07437
Mouse Tubb5 NM_011655 P99024
Rat Tubb5 NM_173102 P69897
Tubulin β1 Human TUBB1 NM_030773 Q9H4B7
Mouse Tubb1 NM_001080971 NP_001074440
Tubulin β2A Human TUBB2A NM_001069 Q13885
Mouse Tubb2a NM_009450 Q7TMM9
Rat Tubb2a NM_001109119 P85108
Tubulin β2B Human TUBB2B NM_178012 Q9BVA1
Mouse Tubb2b NM_023716 Q9CWF2
Rat Tubb2b NM_001013886 Q3KRE8
Tubulin β2C Human TUBB2C NM_006088 P68371
Mouse Tubb2c NM_146116 P68372
Rat Tubb2c NM_199094 Q6P9T8
Tubulin β3 Human TUBB3 NM_006086 Q13509
Mouse Tubb3 NM_023279 Q9ERD7
Rat Tubb3 NM_139254 Q8K5B7
Tubulin β4 Human TUBB4 NM_006087 P04350
Mouse Tubb4 NM_009451 Q9D6F9
Rat Tubb4 NM_080882 Q8VIP3
Tubulin β6 Human TUBB6 NM_032525 Q9BUF5
Mouse Tubb6 NM_026473 Q922F4
Rat Tubb6 NM_001025675 Q4QQV0