Microtubules
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of α- and β-tubulin polymers. Each microtubule is polarized; at one end α-subunits are exposed (-) and at the other, β-subunits are exposed (+).
| Cat. No. | Product Name / Activity |
|---|---|
| 6043 | AMBMP hydrochloride |
| Tubulin polymerization inhibitor; also Wnt canonical signaling activator | |
| 2186 | CMPD-1 |
| Tubulin polymerization inhibitor; also selective inhibitor of p38α-mediated MK2a phosphorylation | |
| 1364 | Colchicine |
| Inhibitor of tubulin | |
| 6273 | CRT 0105950 |
| Disrupts microtubule organization; potent LIMK1/2 inhibitor | |
| 6779 | Davunetide |
| Highly potent active component of ADNP; increases tau-microtubule interactions | |
| 4056 | Docetaxel |
| Microtubule stabilizer | |
| 2226 | Flutax 1 |
| Fluorescent taxol derivative; microtubule stain | |
| 6254 | Flutax 2 |
| Green fluorescent taxol derivative; binds microtubules | |
| 5075 | Harmine |
| Potent and selective Dyrk1A inhibitor; inhibits tau phosphorylation | |
| 3728 | Indibulin |
| Microtubule destabilizer | |
| 4997 | INDY |
| Dyrk1A/B inhibitor; inhibits abberant tau phosphorylation | |
| 3213 | Methylene Blue |
| Inhibitor of tau aggregation | |
| 5231 | MPC 6827 hydrochloride |
| Inhibitor of microtubule polymerization; antimitotic and antitumor | |
| 1228 | Nocodazole |
| Microtubule inhibitor | |
| 1097 | Taxol |
| Promotes assembly and inhibits disassembly of microtubules | |
| 1256 | Vinblastine sulfate |
| Disrupts microtubules | |
| 1257 | Vincristine sulfate |
| Disrupts microtubules | |
| 3401 | Vinorelbine ditartrate |
| Selective mitotic microtubule antagonist |
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of α- and β-tubulin polymers. Each microtubule is polarized, at one end α-subunits are exposed (-) and at the other β-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move along, a process that requires motor proteins.
The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis. Due to this central role in cell division, microtubules are of interest as a therapeutic target in cancer research. Both inhibition of microtubule polymerization and stabilization of the microtubules block cell division, and molecules which affect microtubule assembly are therefore of potential use as anticancer agents.
Literature for Microtubules
Tocris offers the following scientific literature for Microtubules to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Microtubule Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| Tubulin α1A | Human | TUBA1A | NM_006009 | Q71U36 |
| Mouse | Tuba1a | NM_011653 | P68369 | |
| Rat | Tuba1a | NM_022298 | P68370 | |
| Tubulin α1B | Human | TUBA1B | NM_006082 | P68363 |
| Mouse | Tuba1b | NM_011654 | P05213 | |
| Rat | Tuba1b | NM_001044270 | Q6P9V9 | |
| Tubulin α1C | Human | TUBA1C | NM_032704 | Q9BQE3 |
| Mouse | Tuba1c | NM_009448 | P68373 | |
| Rat | Tuba1c | NM_001011995 | Q6AYZ1 | |
| Tubulin α3A | Mouse | Tuba3a | NM_009446 | P05214 |
| Rat | Tuba3a | NM_001040008 | Q68FR8 | |
| Tubulin α3B | Mouse | Tuba3b | NM_009449 | P05214 |
| Rat | Tuba3b | NM_001024336 | Q68FR8 | |
| Tubulin α3C | Human | TUBA3C | NM_006001 | Q13748 |
| Tubulin α3D | Human | TUBA3D | NM_080386 | Q13748 |
| Tubulin α3E | Human | TUBA3E | NM_207312 | Q6PEY2 |
| Tubulin α4A | Human | TUBA4A | NM_006000 | P68366 |
| Mouse | Tuba4a | NM_009447 | P68368 | |
| Rat | Tuba4a | NM_001007004 | Q5XIF6 | |
| Tubulin α8 | Human | TUBA8 | NM_018943 | Q9NY65 |
| Mouse | Tuba8 | NM_017379 | Q9JJZ2 | |
| Rat | Tuba8 | NM_001024339 | Q6AY56 | |
| Tubulin β | Human | TUBB | NM_178014 | P07437 |
| Mouse | Tubb5 | NM_011655 | P99024 | |
| Rat | Tubb5 | NM_173102 | P69897 | |
| Tubulin β1 | Human | TUBB1 | NM_030773 | Q9H4B7 |
| Mouse | Tubb1 | NM_001080971 | NP_001074440 | |
| Tubulin β2A | Human | TUBB2A | NM_001069 | Q13885 |
| Mouse | Tubb2a | NM_009450 | Q7TMM9 | |
| Rat | Tubb2a | NM_001109119 | P85108 | |
| Tubulin β2B | Human | TUBB2B | NM_178012 | Q9BVA1 |
| Mouse | Tubb2b | NM_023716 | Q9CWF2 | |
| Rat | Tubb2b | NM_001013886 | Q3KRE8 | |
| Tubulin β2C | Human | TUBB2C | NM_006088 | P68371 |
| Mouse | Tubb2c | NM_146116 | P68372 | |
| Rat | Tubb2c | NM_199094 | Q6P9T8 | |
| Tubulin β3 | Human | TUBB3 | NM_006086 | Q13509 |
| Mouse | Tubb3 | NM_023279 | Q9ERD7 | |
| Rat | Tubb3 | NM_139254 | Q8K5B7 | |
| Tubulin β4 | Human | TUBB4 | NM_006087 | P04350 |
| Mouse | Tubb4 | NM_009451 | Q9D6F9 | |
| Rat | Tubb4 | NM_080882 | Q8VIP3 | |
| Tubulin β6 | Human | TUBB6 | NM_032525 | Q9BUF5 |
| Mouse | Tubb6 | NM_026473 | Q922F4 | |
| Rat | Tubb6 | NM_001025675 | Q4QQV0 |
Our Cancer Research Guide highlights over 750 products for cancer research.
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Our Cell Cycle and DNA Damage Research Guide highlights over 750 products for cell cycle and DNA damage research.
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