AMG 900

Pricing Availability   Qty
Description: Potent pan-Aurora kinase inhibitor
Chemical Name: N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for AMG 900

AMG 900 is a potent pan-Aurora kinase inhibitor (IC50 values are 1 nM, 4 nM, and 5 nM for Aurora C, B, and A, respectively). It is more than 10-fold selective for Aurora kinases over JNK2, Tie2, p38α, Met, and TYK2. AMG 900 inhibits autophosphorylation of Aurora A and B, as well as the phosphorylation of histone H3 on Ser in HeLa cells. AMG 900 inhibits proliferation of 26 tumor cell lines (EC50 ranges from 0.7 nM - 5.3 nM), including Paclitaxel (Cat. No. 1097)-resistant tumor cell lines. In an HCT116 tumor xenograft model, AMG 900 inhibits phosphorylation of histone H3 and tumor growth. It is orally bioavailable.

Technical Data for AMG 900

M. Wt 503.58
Formula C28H21N7OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 945595-80-2
PubChem ID 24856041
Smiles N1=NC(C=2SC=C(C2)C)=C3C=CC=CC3=C1NC4=CC=C(OC=5N=CC=CC5C6=NC(=NC=C6)N)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AMG 900

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.04 10 with gentle warming

Preparing Stock Solutions for AMG 900

The following data is based on the product molecular weight 503.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.86 mL 99.29 mL 198.58 mL
0.5 mM 3.97 mL 19.86 mL 39.72 mL
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL

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References for AMG 900

References are publications that support the biological activity of the product.

Payton et al (2010) Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 70 9846 PMID: 20935223

If you know of a relevant reference for AMG 900, please let us know.

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Citations for AMG 900

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Currently there are no citations for AMG 900. Do you know of a great paper that uses AMG 900 from Tocris? Please let us know.

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Literature in this Area

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