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Submit ReviewS-Trityl-L-cysteine
Description: Potent, selective inhibitor of mitotic kinesin Eg5
Alternative Names: NSC 83265
Chemical Name: S-(Triphenylmethyl)-L-cysteine
Biological Activity for S-Trityl-L-cysteine
S-Trityl-L-cysteine is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity.
Technical Data for S-Trityl-L-cysteine
| M. Wt | 363.47 |
| Formula | C22H21NO2S |
| Storage | Store at +4°C |
| CAS Number | 2799-07-7 |
| PubChem ID | 7271795 |
| InChI Key | DLMYFMLKORXJPO-HXUWFJFHSA-N |
| Smiles | N[C@@H](C(O)=O)CSC(C2=CC=CC=C2)(C3=CC=CC=C3)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for S-Trityl-L-cysteine
References for S-Trityl-L-cysteine
References are publications that support the biological activity of the product.
DeBonis et al (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities. Mol.Cancer Ther. 3 1079 PMID: 15367702
Brier et al (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5. Biochemistry 43 13072 PMID: 15476401
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Keywords: S-Trityl-L-cysteine, S-Trityl-L-cysteine supplier, Potent, selective, inhibitors, inhibits, mitotic, kinesin, Eg5, Mitotic, Kinesin, Mitosis, NSC83265, NSC, 83265, 2191, Tocris Bioscience
6 Citations for S-Trityl-L-cysteine
Citations are publications that use Tocris products. Selected citations for S-Trityl-L-cysteine include:
Hengeveld (2017) Inner centromere localization of the CPC maintains centromere cohesion and allows mitoticcheckpoint silencing. Nat Commun 8 15542 PMID: 28561035
Hindriksen et al (2017) Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. PLoS One 12 e0179514 PMID: 28640891
Cilibrasi et al (2019) A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition. J Oncol 2019 9014045 PMID: 31531022
Ferreira et al (2018) Dissecting the role of the tubulin code in mitosis. Methods Cell Biol 144 33 PMID: 29804676
Müllers et al (2014) Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. PLoS Genet 13 2733 PMID: 25486360
Hégarat et al (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. J Pharmacol Exp Ther 10 e1004004 PMID: 24391510
Reviews for S-Trityl-L-cysteine
Average Rating: 4 (Based on 1 Review.)
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STLC block cells at mitotic entry.
By
Valeria Marotta on 10/07/2020
Species: Human
Cell Line/Tissue: U2OS
I used the product to synchronise the cells at mitotic entry.
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets