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Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 363.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.5 mL||27.51 mL||55.03 mL|
|2.5 mM||1.1 mL||5.5 mL||11.01 mL|
|5 mM||0.55 mL||2.75 mL||5.5 mL|
|25 mM||0.11 mL||0.55 mL||1.1 mL|
References are publications that support the biological activity of the product.
DeBonis et al (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities. Mol.Cancer Ther. 3 1079 PMID: 15367702
Brier et al (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5. Biochemistry 43 13072 PMID: 15476401
If you know of a relevant reference for S-Trityl-L-cysteine, please let us know.
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Keywords: S-Trityl-L-cysteine, S-Trityl-L-cysteine supplier, Potent, selective, inhibitors, inhibits, mitotic, kinesin, Eg5, Mitotic, Kinesin, Mitosis, NSC83265, NSC, 83265, 2191, Tocris Bioscience
6 Citations for S-Trityl-L-cysteine
Citations are publications that use Tocris products. Selected citations for S-Trityl-L-cysteine include:
Cilibrasi et al (2019) A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition. J Oncol 2019 9014045 PMID: 31531022
Ferreira et al (2018) Dissecting the role of the tubulin code in mitosis. Methods Cell Biol 144 33 PMID: 29804676
Hindriksen et al (2017) Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. PLoS One 12 e0179514 PMID: 28640891
Hengeveld (2017) Inner centromere localization of the CPC maintains centromere cohesion and allows mitoticcheckpoint silencing. Nat Commun 8 15542 PMID: 28561035
Müllers et al (2014) Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. PLoS Genet 13 2733 PMID: 25486360
Hégarat et al (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. J Pharmacol Exp Ther 10 e1004004 PMID: 24391510
Do you know of a great paper that uses S-Trityl-L-cysteine from Tocris? Please let us know.
Reviews for S-Trityl-L-cysteine
Average Rating: 4 (Based on 1 Review.)
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Literature in this Area
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