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Cat.No. 2191 - S-Trityl-L-cysteine | C22H21NO2S | CAS No. 2799-07-7
Description: Potent, selective inhibitor of mitotic kinesin Eg5
Alternative Names: NSC 83265
Chemical Name: S-(Triphenylmethyl)-L-cysteine
Citations (3)

Biological Activity

Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity.

Technical Data

M. Wt 363.47
Formula C22H21NO2S
Storage Store at +4°C
CAS Number 2799-07-7
PubChem ID 7271795
Smiles N[C@@H](C(O)=O)CSC(C2=CC=CC=C2)(C3=CC=CC=C3)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 18.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 363.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.51 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References are publications that support the products' biological activity.

DeBonis et al (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities. Mol.Cancer Ther. 3 1079 PMID: 15367702

Brier et al (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5. Biochemistry 43 13072 PMID: 15476401

If you know of a relevant reference for S-Trityl-L-cysteine, please let us know.

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Keywords: S-Trityl-L-cysteine, supplier, Potent, selective, inhibitors, inhibits, mitotic, kinesin, Eg5, Mitotic, Kinesin, Mitosis, NSC83265, NSC, 83265, Kinesin, Mitosis, Kinesin, Tocris Bioscience

3 Citations for S-Trityl-L-cysteine

Citations are publications that use Tocris products. Selected citations for S-Trityl-L-cysteine include:

Hengeveld  (2017) Inner centromere localization of the CPC maintains centromere cohesion and allows mitoticcheckpoint silencing. Nat Commun 8 15542 PMID: 28561035

Müllers et al (2014) Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. PLoS Genet 13 2733 PMID: 25486360

Hégarat et al (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. J Pharmacol Exp Ther 10 e1004004 PMID: 24391510

Do you know of a great paper that uses S-Trityl-L-cysteine from Tocris? If so please let us know.

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