Colchicine

Pricing Availability Delivery Time Qty
Cat.No. 1364 - Colchicine | C22H25NO6 | CAS No. 64-86-8
Description: Inhibitor of tubulin
Chemical Name: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules.

Technical Data

M. Wt 399.44
Formula C22H25NO6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 64-86-8
PubChem ID 2833
InChI Key IAKHMKGGTNLKSZ-UHFFFAOYSA-N
Smiles COC1=C(OC)C(OC)=C2C(CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.94 100
ethanol 100
water 39.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 399.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.52 mL 25.04 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bai et al (1996) Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colchicine. J.Biol.Chem. 271 12639 PMID: 8647876

Burns (1992) Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 297 205 PMID: 1544399

Hastie (1991) Interactions of colchicine with tubulin. Pharmacol.Ther. 51 377 PMID: 1792241


If you know of a relevant reference for Colchicine, please let us know.

Keywords: inhibitors inhibits tubulin Tau Tubulin Microtubules Mitosis Microtubules

1 Citation for Colchicine

Citations are publications that use Tocris products. Selected citations for Colchicine include:

Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007


Do you know of a great paper that uses Colchicine from Tocris? If so please let us know.

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Pathways for Colchicine

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