Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 399.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.5 mL||12.52 mL||25.04 mL|
|5 mM||0.5 mL||2.5 mL||5.01 mL|
|10 mM||0.25 mL||1.25 mL||2.5 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bai et al (1996) Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colchicine. J.Biol.Chem. 271 12639 PMID: 8647876
Burns (1992) Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 297 205 PMID: 1544399
Hastie (1991) Interactions of colchicine with tubulin. Pharmacol.Ther. 51 377 PMID: 1792241
If you know of a relevant reference for Colchicine, please let us know.
Keywords: inhibitors inhibits tubulin Tau Tubulin Microtubules Mitosis Microtubules
1 Citation for Colchicine
Citations are publications that use Tocris products. Selected citations for Colchicine include:
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007
Do you know of a great paper that uses Colchicine from Tocris? If so please let us know.