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Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. Identified as a candidate for repurposing for COVID-19. Inhibits NLRP3 inflammasomes. Also decreases TNF-α receptor expression and reduces cytokine levels in macrophages. Anti-inflammatory.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 399.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.5 mL||12.52 mL||25.04 mL|
|5 mM||0.5 mL||2.5 mL||5.01 mL|
|10 mM||0.25 mL||1.25 mL||2.5 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References are publications that support the biological activity of the product.
Bai et al (1996) Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colch. J.Biol.Chem. 271 12639 PMID: 8647876
Burns (1992) Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 297 205 PMID: 1544399
Hastie (1991) Interactions of colch. with tubulin. Pharmacol.Ther. 51 377 PMID: 1792241
Morselli et al (2020) Network medicine framework for identifying drug repurposing opportunities for COVID-19. arXiv - Paper not yet peer reviewed PMID: 32550253
Ribeiro et al (2020) The therapeutic potential of colch in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? Metabol.Open 7 100045 PMID: 32808940
Martinez et al (2018) The NLRP3 inflammasome and the emerging role of colch to inhibit atherosclerosis-associated inflammation. Atherosclerosis 269 262 PMID: 29352570
If you know of a relevant reference for Colchicine, please let us know.
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Keywords: Colchicine, Colchicine supplier, inhibitors, inhibits, tubulin, Tau, Tubulin, Microtubules, Mitosis, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, inflammasome, NLRP3, Inflammasomes, 1364, Tocris Bioscience
5 Citations for Colchicine
Citations are publications that use Tocris products. Selected citations for Colchicine include:
Khan et al (2016) Genetic screening reveals a link between Wnt signaling and antitubulin drugs. Pharmacogenomics J 16 164 PMID: 26149735
Park et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17 914 PMID: 27270401
Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007
Melemedjian et al (2014) Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Mol Pain 10 45 PMID: 24993495
Do you know of a great paper that uses Colchicine from Tocris? Please let us know.
Reviews for Colchicine
Average Rating: 5 (Based on 1 Review.)
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Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
Literature in this Area
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