Colchicine

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Cat.No. 1364 - Colchicine | C22H25NO6 | CAS No. 64-86-8
Description: Inhibitor of tubulin
Chemical Name: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews (1)
Literature (2)

Biological Activity

Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. Identified as a candidate for repurposing for COVID-19.

Technical Data

M. Wt 399.44
Formula C22H25NO6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 64-86-8
PubChem ID 2833
InChI Key IAKHMKGGTNLKSZ-UHFFFAOYSA-N
Smiles COC1=C(OC)C(OC)=C2C(CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 39.94 100
DMSO 39.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 399.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.52 mL 25.04 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bai et al (1996) Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colch. J.Biol.Chem. 271 12639 PMID: 8647876

Burns (1992) Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 297 205 PMID: 1544399

Hastie (1991) Interactions of colch. with tubulin. Pharmacol.Ther. 51 377 PMID: 1792241

Morselli et al (2020) Network medicine framework for identifying drug repurposing opportunities for COVID-19. arXiv - Paper not yet peer reviewed PMID: 32550253


If you know of a relevant reference for Colchicine, please let us know.

Keywords: Colchicine, Colchicine supplier, inhibitors, inhibits, tubulin, Tau, Tubulin, Microtubules, Mitosis, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, 1364, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Colchicine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

5 Citations for Colchicine

Citations are publications that use Tocris products. Selected citations for Colchicine include:

Melemedjian et al (2014) Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Mol Pain 10 45 PMID: 24993495

Khan et al (2016) Genetic screening reveals a link between Wnt signaling and antitubulin drugs. Pharmacogenomics J 16 164 PMID: 26149735

Park et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17 914 PMID: 27270401

Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007


Do you know of a great paper that uses Colchicine from Tocris? Please let us know.

Reviews for Colchicine

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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma.
By Anonymous on 11/17/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Human epidermal carcinoma cell line

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007
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