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Biological Activity for proTAME
ProTAME is a cell-permeable APC/C (anaphase-promoting complex/cyclosome) inhibitor. It is converted to TAME (Tosyl-L-Arginine Methyl Ester) by intracellular esterases. It induces cell cycle arrest in metaphase followed by cell death.
Technical Data for proTAME
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for proTAME
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for proTAME
The following data is based on the product molecular weight 726.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||2.75 mL||13.76 mL||27.52 mL|
|2.5 mM||0.55 mL||2.75 mL||5.5 mL|
|5 mM||0.28 mL||1.38 mL||2.75 mL|
|25 mM||0.06 mL||0.28 mL||0.55 mL|
References for proTAME
References are publications that support the biological activity of the product.
Zeng et al (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 18 382 PMID: 20951947
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Citations for proTAME
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Literature in this Area
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.