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Description: Cell-permeable APC/C inhibitor
Chemical Name: Methyl (2S)-2-[[(4-methylphenyl)sulfonyl]amino]-9,13-dioxo-14-phenyl-7-[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]-10,12-dioxa-6,8-diazatetradec-6-enoate
Purity: ≥90% (HPLC)
Literature (1)

Biological Activity for proTAME

ProTAME is a cell-permeable APC/C (anaphase-promoting complex/cyclosome) inhibitor. It is converted to TAME (Tosyl-L-Arginine Methyl Ester) by intracellular esterases. It induces cell cycle arrest in metaphase followed by cell death.

Technical Data for proTAME

M. Wt 726.75
Formula C34H38N4O12S
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 1362911-19-0
PubChem ID 56924780
Smiles O=C([C@@H](NS(=O)(C1=CC=C(C=C1)C)=O)CCC/N=C(NC(OCOC(CC2=CC=CC=C2)=O)=O)/NC(OCOC(CC3=CC=CC=C3)=O)=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for proTAME

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.34 50

Preparing Stock Solutions for proTAME

The following data is based on the product molecular weight 726.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.75 mL 13.76 mL 27.52 mL
2.5 mM 0.55 mL 2.75 mL 5.5 mL
5 mM 0.28 mL 1.38 mL 2.75 mL
25 mM 0.06 mL 0.28 mL 0.55 mL

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References for proTAME

References are publications that support the biological activity of the product.

Zeng et al (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 18 382 PMID: 20951947

If you know of a relevant reference for proTAME, please let us know.

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Keywords: proTAME, proTAME supplier, cell, cycle, meiosis, mitosis, anaphase, promoting, complex, cyclosome, metaphase, TAME, apoptosis, cell-permeable, Mitosis, 7734, Tocris Bioscience

Citations for proTAME

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.