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Selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 297.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.36 mL||16.79 mL||33.59 mL|
|5 mM||0.67 mL||3.36 mL||6.72 mL|
|10 mM||0.34 mL||1.68 mL||3.36 mL|
|50 mM||0.07 mL||0.34 mL||0.67 mL|
References are publications that support the biological activity of the product.
Braun et al (2014) Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A. ACS Chem.Biol. 10 554 PMID: 25402598
Catarinella et al (2009) BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew.Chem.Int.Ed.Engl. 48 9072 PMID: 19856362
If you know of a relevant reference for BTB1, please let us know.
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Keywords: BTB1, BTB1 supplier, Selective, reversible, ATP-competitive, mitotic, Kinesins, Kif18A, inhibitors, inhibits, microtubule, mitosis, Kinesin, Mitosis, 5399, Tocris Bioscience
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