Pricing Availability   Qty
Description: Selective and ATP-competitive Kif18A inhibitor
Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for BTB1

BTB1 is a selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.

Technical Data for BTB1

M. Wt 297.71
Formula C12H8ClNO4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 86030-08-2
PubChem ID 291461
Smiles ClC1=CC([N+]([O-])=O)=C(S(C2=CC=CC=C2)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BTB1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.77 100
ethanol 5.95 20

Preparing Stock Solutions for BTB1

The following data is based on the product molecular weight 297.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.79 mL 33.59 mL
5 mM 0.67 mL 3.36 mL 6.72 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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References for BTB1

References are publications that support the biological activity of the product.

Braun et al (2014) Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A. ACS Chem.Biol. 10 554 PMID: 25402598

Catarinella et al (2009) BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew.Chem.Int.Ed.Engl. 48 9072 PMID: 19856362

If you know of a relevant reference for BTB1, please let us know.

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Keywords: BTB1, BTB1 supplier, Selective, reversible, ATP-competitive, mitotic, Kinesins, Kif18A, inhibitors, inhibits, microtubule, mitosis, Kinesin, Mitosis, 5399, Tocris Bioscience

Citations for BTB1

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

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