BTB1

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Cat.No. 5399 - BTB1 | C12H8ClNO4S | CAS No. 86030-08-2
Description: Selective and ATP-competitive Kif18A inhibitor
Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.

Compound Libraries

BTB1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 297.71
Formula C12H8ClNO4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 86030-08-2
PubChem ID 291461
InChI Key VZDUQPHKUBZMLW-UHFFFAOYSA-N
Smiles ClC1=CC([N+]([O-])=O)=C(S(C2=CC=CC=C2)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.77 100
ethanol 5.95 20

Preparing Stock Solutions

The following data is based on the product molecular weight 297.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.79 mL 33.59 mL
5 mM 0.67 mL 3.36 mL 6.72 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Braun et al (2014) Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A. ACS Chem.Biol. 10 554 PMID: 25402598

Catarinella et al (2009) BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew.Chem.Int.Ed.Engl. 48 9072 PMID: 19856362


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View all Kinesin Inhibitors

Keywords: BTB1, supplier, Selective, reversible, ATP-competitive, mitotic, Kinesins, Kif18A, inhibitors, inhibits, microtubule, mitosis, Kinesin, Mitosis, Kinesin, Tocris Bioscience

Citations for BTB1

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Literature in this Area

Cancer

Cancer Research Product Guide

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Pathways for BTB1

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