A fluorescent taxol derivative that binds to the taxol microtubule binding site with high affinity (Ka ~ 107M-1). Useful for direct imaging of the microtubule cytoskeleton. Excitation maximum ~ 495 nm; emission maximum ~ 520 nm.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1283.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.78 mL||3.9 mL||7.79 mL|
|5 mM||0.16 mL||0.78 mL||1.56 mL|
|10 mM||0.08 mL||0.39 mL||0.78 mL|
|50 mM||0.02 mL||0.08 mL||0.16 mL|
References are publications that support the biological activity of the product.
Diaz et al (2000) Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site. J.Biol.Chem. 275 26265 PMID: 10818101
Diaz et al (2003) Fast kinetics of taxol binding to microtubules. J.Biol.Chem. 278 8407 PMID: 12496245
Evangelio et al (1998) Fluorescent taxoids as probes of the microtubule cytoskeleton. Cell Motil.Cytoskel. 39 73
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Keywords: Flutax 1, Flutax 1 supplier, Fluorescent, taxol, derivative, Mitosis, Probes, Tau, Tubulin, Microtubules, Flutax1, 2226, Tocris Bioscience
2 Citations for Flutax 1
Citations are publications that use Tocris products. Selected citations for Flutax 1 include:
Kaittanis et al (2014) Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nat Commun 5 3384 PMID: 24594970
Kaittanis et al (2015) Multifunctional MRI/PET Nanobeacons Derived from the in Situ Self-Assembly of Translational Polymers and Clinical Cargo through Coalescent Intermolecular Forces. Nano Lett 15 8032 PMID: 26540670
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