Flutax 1

Pricing Availability Delivery Time Qty
Cat.No. 2226 - Flutax 1 | C71H66N2O21 | CAS No. 191930-58-2
Description: Fluorescent taxol derivative
Chemical Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

A fluorescent taxol derivative that binds to the taxol microtubule binding site with high affinity (Ka ~ 107M-1). Useful for direct imaging of the microtubule cytoskeleton. Excitation maximum ~ 495 nm; emission maximum ~ 520 nm.

Technical Data

M. Wt 1283.3
Formula C71H66N2O21
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 191930-58-2
PubChem ID 16760423
InChI Key JMWJJMCMRRQCSY-ADONSEPTSA-N
Smiles O=C2[C@@]3(C)C([C@@]4(OC(C)=O)[C@H](OC4)C[C@@H]3OC([C@H](C)NC(C7=CC=C(C8=C(C=C%10)C(OC9=C8C=CC(O)=C9)=CC%10=O)C(C(O)=O)=C7)=O)=O)[C@H](OC(C6=CC=CC=C6)=O)[C@@]1(O)[C@](C)(C)C([C@H]2OC(C)=O)=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(C%11=CC=CC=C%11)=O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 128.33 100
ethanol 128.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 1283.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.78 mL 3.9 mL 7.79 mL
5 mM 0.16 mL 0.78 mL 1.56 mL
10 mM 0.08 mL 0.39 mL 0.78 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Diaz et al (2000) Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site. J.Biol.Chem. 275 26265 PMID: 10818101

Diaz et al (2003) Fast kinetics of taxol binding to microtubules. J.Biol.Chem. 278 8407 PMID: 12496245

Evangelio et al (1998) Fluorescent taxoids as probes of the microtubule cytoskeleton. Cell Motil.Cytoskel. 39 73 PMID:


If you know of a relevant reference for Flutax 1, please let us know.

Keywords: Flutax 1, supplier, Fluorescent, taxol, derivative, Mitosis, Probes, Tau, Tubulin, Microtubules, Flutax1, Microtubules, Mitosis, Fluorescent, Probes, Microtubules, Tocris Bioscience

1 Citation for Flutax 1

Citations are publications that use Tocris products. Selected citations for Flutax 1 include:

Kaittanis et al (2014) Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nat Commun 5 3384 PMID: 24594970


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