Mdivi 1

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Cat.No. 3982 - Mdivi 1 | C15H10Cl2N2O2S | CAS No. 338967-87-6
Description: Dynamin inhibitor; attenuates mitochondrial division and apoptosis
Chemical Name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective inhibitor of Dnm1 GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. Inhibits autophagy.

Technical Data

M. Wt 353.22
Formula C15H10Cl2N2O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 338967-87-6
PubChem ID 3825829
InChI Key NZJKEVWTYMOYOR-UHFFFAOYSA-N
Smiles O=C2N(C3=C(Cl)C=C(Cl)C(OC)=C3)C(S)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 353.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.16 mL 28.31 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Tanaka and Youle (2008) A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol.Cell 29 409 PMID: 18313377

Lackner et al (2010) Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine. Chem.Biol. 17 57 PMID: 20142041

Cassidy-Stone et al (2008) Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Develop.Cell 14 193 PMID:

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 8529316


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Keywords: selective inhibitors inhibits inhibitor dynamin Dnm1 dynamin-related GTPases DRP attenuates mitochondrial division Mdivi1 DRP1 GTPase

Citations for Mdivi 1

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Mdivi 1

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