Mdivi 1

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Description: Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis
Chemical Name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Purity: ≥98% (HPLC)
Citations (7)

Biological Activity for Mdivi 1

Mdivi 1 is a selective inhibitor of dynamin GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.

Technical Data for Mdivi 1

M. Wt 353.22
Formula C15H10Cl2N2O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 338967-87-6
PubChem ID 3825829
Smiles O=C2N(C3=C(Cl)C=C(Cl)C(OC)=C3)C(S)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mdivi 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.32 100

Preparing Stock Solutions for Mdivi 1

The following data is based on the product molecular weight 353.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.16 mL 28.31 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets for Mdivi 1

Certificate of Analysis / Product Datasheet
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References for Mdivi 1

References are publications that support the biological activity of the product.

Tanaka and Youle (2008) A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol.Cell 29 409 PMID: 18313377

Lackner et al (2010) Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine. Chem.Biol. 17 57 PMID: 20142041

Cassidy-Stone et al (2008) Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Develop.Cell 14 193

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

Park et al (2011) A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest.Ophthalmol Vis.Sci. 52 2837 PMID: 21372007

Ruiz et al (2018) Mitochondrial division inhibitor 1 (mdivi-1) protects neurons against excitotoxicity through the modulation of mitochondrial function and intracellular Ca 2+ signaling. Front.Mol.Neurosci. PMID: 29386996

Manczak and Reddy (2015) Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease. Hum.Mol.Genet. 24 7308 PMID: 26464486

If you know of a relevant reference for Mdivi 1, please let us know.

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7 Citations for Mdivi 1

Citations are publications that use Tocris products. Selected citations for Mdivi 1 include:

Iqbal (2014) Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts. Am J Physiol Cell Physiol 306 C1176 PMID: 24740540

Tao et al (2020) Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity. Redox Biol 37 101706 PMID: 32911435

Xu et al (2017) Mdivi-1 attenuates sodium azide-induced apoptosis in H9c2 cardiac muscle cells. Mol Med Rep 16 5972 PMID: 28849092

Tsuyoshi et al (2017) Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest. Oncotarget 8 99825 PMID: 29245943

Do you know of a great paper that uses Mdivi 1 from Tocris? Please let us know.

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