Selective inhibitor of Dnm1 GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. Inhibits autophagy.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 353.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.83 mL||14.16 mL||28.31 mL|
|5 mM||0.57 mL||2.83 mL||5.66 mL|
|10 mM||0.28 mL||1.42 mL||2.83 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Tanaka and Youle (2008) A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol.Cell 29 409 PMID: 18313377
Lackner et al (2010) Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine. Chem.Biol. 17 57 PMID: 20142041
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 8529316
If you know of a relevant reference for Mdivi 1, please let us know.
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Keywords: selective inhibitors inhibits inhibitor dynamin Dnm1 dynamin-related GTPases DRP attenuates mitochondrial division Mdivi1 DRP1 GTPase
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