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Cat.No. 2897 - Dynasore | C18H14N2O4 | CAS No. 304448-55-3
Description: Non-competitive dynamin inhibitor
Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Purity: ≥99% (HPLC)
Citations (18)

Biological Activity

Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.

Technical Data

M. Wt 322.32
Formula C18H14N2O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 304448-55-3
PubChem ID 5717066
Smiles O=C(N/N=C/C3=CC(O)=C(O)C=C3)C2=CC1=CC=CC=C1C=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.23 100
ethanol 1.61 5

Preparing Stock Solutions

The following data is based on the product molecular weight 322.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.51 mL 31.03 mL
5 mM 0.62 mL 3.1 mL 6.21 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Thompson and McNiven (2006) Discovery of a new 'dynasore'. Nat.Chem.Biol. 2 355 PMID: 16783339

Macia et al (2006) Dynasore, a cell-permeable inhibitor of Dynamin. Develop.Cell 10 839 PMID:

Newton et al (2006) Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc.Natl.Acad.Sci.USA 103 17955 PMID:

If you know of a relevant reference for Dynasore, please let us know.

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Keywords: Dynasore, supplier, Non-competitive, dynamin, 1, 2, mitochondrial, Drp1, inhibitors, inhibits, Mitosis, GTPases, GTPase, Mitosis, GTPase, Tocris Bioscience

18 Citations for Dynasore

Citations are publications that use Tocris products. Selected citations for Dynasore include:

Park et al (2011) A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. J Neurosci 52 2837 PMID: 21372007

Lussier et al (2011) Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. Proc Natl Acad Sci U S A 31 3077 PMID: 21414928

Pribiag and Stellwagen (2013) TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors. J Neurosci 33 15879 PMID: 24089494

Blume et al (2016) Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner. J.Neurochem. 139 396 PMID: 27513693

Nimlamool et al (2015) Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization. Mol Biol Cell 26 2755 PMID: 26063728

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Eur J Cell Biol 10 e0131430 PMID: 26102354

Bassani et al (2012) The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking. Neuron 73 1143 PMID: 22445342

Chandrasekaran et al (2012) HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination. J Biol Chem 287 41481 PMID: 23071112

Proszynski et al (2009) Podosomes are present in a postsynaptic apparatus and participate in its maturation. PLoS One 106 18373 PMID: 19822767

Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Mol Biol Cell 29 15551 PMID: 20007479

Kolpak et al (2009) Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. Invest Ophthalmol Vis Sci 29 10488 PMID: 19710302

Niederst et al (2015) Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Front Immunol 26 205 PMID: 25392299

Hoven et al (2015) eIF2α Confers Cellular Tolerance to S. aureus α-Toxin. Proc Natl Acad Sci U S A 6 383 PMID: 26284068

Lee et al (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. J Neurosci 111 E5114 PMID: 25385580

Marcello et al (2013) Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. J Clin Invest 123 2523 PMID: 23676497

Rodriguez et al (2011) Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells. Leuk Lymphoma 52 2169 PMID: 21870996

Zemskov et al (2011) Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes. PLoS One 6 e19414 PMID: 21556374

Lowther et al (2011) Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest. Reproduction 141 737 PMID: 21411693

Do you know of a great paper that uses Dynasore from Tocris? If so please let us know.

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Literature in this Area

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