TC-S 7005

Pricing Availability Delivery Time Qty
Cat.No. 4459 - TC-S 7005 | C21H17N3O3 | CAS No. 1082739-92-1
Description: Potent and selective PLK2 inhibitor
Chemical Name: 3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

Compound Libraries

TC-S 7005 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 359.38
Formula C21H17N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1082739-92-1
PubChem ID 24971422
InChI Key DAAGOCSHXCDWDY-ZDUSSCGKSA-N
Smiles C[C@H](NC2=CC(C(C4=CC=C(OCO5)C5=C4)=NO3)=C3C=N2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 359.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.91 mL 27.83 mL
5 mM 0.56 mL 2.78 mL 5.57 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hanan et al (2008) Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg.Med.Chem.Lett. 18 5186 PMID: 18790636


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Citations for TC-S 7005

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Cell Cycle & DNA Damage Repair Poster

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