TC-S 7005

Pricing Availability Delivery Time Qty
Cat.No. 4459 - TC-S 7005 | C21H17N3O3 | CAS No. 1082739-92-1
Description: Potent and selective PLK2 inhibitor
Chemical Name: 3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine
Purity: ≥98% (HPLC)

Biological Activity

Potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

Compound Libraries

TC-S 7005 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 359.38
Formula C21H17N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1082739-92-1
PubChem ID 24971422
Smiles C[C@H](NC2=CC(C(C4=CC=C(OCO5)C5=C4)=NO3)=C3C=N2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 359.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.91 mL 27.83 mL
5 mM 0.56 mL 2.78 mL 5.57 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Hanan et al (2008) Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg.Med.Chem.Lett. 18 5186 PMID: 18790636

If you know of a relevant reference for TC-S 7005, please let us know.

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Keywords: TC-S7005 potent selective PLK2 inhibitors inhibits PLK1 PLK3 TCS7005 mitosis PLK cell cycle kinases polo-like polo like Polo-like Kinase

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