TC-S 7005

Pricing Availability   Qty
Description: Potent and selective PLK2 inhibitor
Chemical Name: 3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine
Purity: ≥98% (HPLC)
Citations (1)
Literature (3)

Biological Activity for TC-S 7005

TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

Compound Libraries for TC-S 7005

TC-S 7005 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for TC-S 7005

M. Wt 359.38
Formula C21H17N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1082739-92-1
PubChem ID 24971422
Smiles C[C@H](NC2=CC(C(C4=CC=C(OCO5)C5=C4)=NO3)=C3C=N2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-S 7005

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.94 100

Preparing Stock Solutions for TC-S 7005

The following data is based on the product molecular weight 359.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.91 mL 27.83 mL
5 mM 0.56 mL 2.78 mL 5.57 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for TC-S 7005

Certificate of Analysis / Product Datasheet
Select another batch:

References for TC-S 7005

References are publications that support the biological activity of the product.

Hanan et al (2008) Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg.Med.Chem.Lett. 18 5186 PMID: 18790636

If you know of a relevant reference for TC-S 7005, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Polo-like Kinase Inhibitors

Keywords: TC-S 7005, TC-S 7005 supplier, TC-S7005, potent, selective, PLK2, inhibitors, inhibits, PLK1, PLK3, TCS7005, mitosis, PLK, cell, cycle, kinases, polo-like, polo, like, Polo-like, Kinase, Mitosis, 4459, Tocris Bioscience

1 Citation for TC-S 7005

Citations are publications that use Tocris products. Selected citations for TC-S 7005 include:

Arimoto et al (2023) Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis Nat Commun 14 251 PMID: 36646704

Do you know of a great paper that uses TC-S 7005 from Tocris? Please let us know.

Reviews for TC-S 7005

There are currently no reviews for this product. Be the first to review TC-S 7005 and earn rewards!

Have you used TC-S 7005?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.