Centrinone B

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Description: High affinity and selective PLK4 inhibitor
Alternative Names: LCR 323
Chemical Name: 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine
Purity: ≥98% (HPLC)
Citations (8)
Reviews (1)
Literature (2)

Biological Activity for Centrinone B

Centrinone B is a high affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.

Licensing Information

Sold with the permission of the Ludwig Institute for Cancer Research Ltd

Technical Data for Centrinone B

M. Wt 631.67
Formula C27H27F2N7O5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1798871-31-4
PubChem ID 118704753
Smiles FC1=C([N+]([O-])=O)C=CC=C1CS(C2=CC=C(SC3=NC(N4CCCCC4)=C(OC)C(NC5=NNC(C)=C5)=N3)C(F)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Centrinone B

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.58 50

Preparing Stock Solutions for Centrinone B

The following data is based on the product molecular weight 631.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.17 mL 15.83 mL 31.66 mL
2.5 mM 0.63 mL 3.17 mL 6.33 mL
5 mM 0.32 mL 1.58 mL 3.17 mL
25 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets for Centrinone B

Certificate of Analysis / Product Datasheet
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References for Centrinone B

References are publications that support the biological activity of the product.

Wong et al (2015) Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science 348 1155 PMID: 25931445

If you know of a relevant reference for Centrinone B, please let us know.

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Keywords: Centrinone B, Centrinone B supplier, LCR323, high, affinity, selective, PLK4, inhibitors, inhibits, centriole, centrosome, LCR, 323, Polo-like, Kinase, Mitosis, 5690, Tocris Bioscience

8 Citations for Centrinone B

Citations are publications that use Tocris products. Selected citations for Centrinone B include:

Kazazian et al (2017) Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton. Cancer Res 77 434 PMID: 27872092

Mues et al (2019) High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep 27 631 PMID: 30970263

Chen et al (2017) Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles. Nat Commun 8 247 PMID: 28811500

Péter et al (2022) Centrosome function is critical during terminal erythroid differentiation. EMBO J 41 e108739 PMID: 35678476

Do you know of a great paper that uses Centrinone B from Tocris? Please let us know.

Reviews for Centrinone B

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T-ALL Network and Pharmacological Validation of Synthetic Lethal Screen.
By Anonymous on 03/26/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: T cell line


PMID: 30970263
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.