Dynamin

Dynamins (EC 3.6.5.5) are multi-domain, high molecular weight GTPases, which play a key role in receptor-mediated endocytosis, synaptic vesicle recycling, motility of cancer cells and spermatogenesis. Mutations in DNM2 have been linked to neuromuscular diseases.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
1774 Dynamin inhibitory peptide
Dynamin inhibitor
1775 Dynamin inhibitory peptide, myristoylated
Cell-permeable dynamin inhibitor
1776 Dynamin inhibitory peptide, myristoylated (control)
Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775)
2897 Dynasore
Non-competitive dynamin inhibitor
4222 Dynole 34-2
Dynamin I inhibitor
5364 Hydroxy Dynasore
Dynamin inhibitor; analog of dynasore (Cat. No. 2897)
3982 Mdivi 1
Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis
4224 MitMAB
Dynamin inhibitor
4225 OctMAB
Dynamin inhibitor

Dynamins (EC 3.6.5.5) are multi-domain, high molecular weight GTPases, which play a key role in receptor-mediated endocytosis, synaptic vesicle recycling, focal adhesion assembly, cytoskeletal changes, motility of cancer cells and spermatogenesis. The dynamin family also includes dynamin-like proteins.

In mammals, there are three classical dynamins, each coded by a different gene, with varying expression patterns. Dynamin I is predominantly expressed in neurons and mediates synaptic vesicle recycling. Dynamin II is ubiquitously expressed and is involved in receptor mediated endocytosis, including uptake of viral and bacterial pathogens. The highest levels of dynamin III are found in the lung, testes and post-synaptic neurons and has been implicated in post-synaptic AMPA receptor recycling.

Dynamin proteins have various domains associated with different functions: the N-terminal GTPase domain to binds and hydrolyzes GTP; pleckstrin homology (PH) domains, which bind acidic membrane phospholipids; and C-terminal proline rich (PR) domains that mediate protein-protein interactions. Dynamin-like proteins, which assist in recruiting classical dynamins to cleave vesicles from the cell membrane, lack PH and PR domains.

Dynamins are associated with a range of disorders including, but not limited to, Alzheimer's disease, cancer metastasis, epilepsy, Huntington's disease and Parkinson's disease. Mutations in the dynamin II gene have been linked to two neuromuscular diseases; Centronuclear myopathy, and intermediate and axonal forms of Charcot-Marie Tooth disease.

External sources of pharmacological information for Dynamin :

    Literature for Dynamin

    Tocris offers the following scientific literature for Dynamin to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    Dynamin Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Dynamin 1 Human DNM1 NM_004408 Q05193
    Mouse Dnm1 NM_010065 P39053
    Rat Dnm1 NM_080689 P21575
    Dynamin 2 Human DNM2 NM_004945 P50570
    Mouse Dnm2 NM_001039520 P39054
    Rat Dnm2 NM_013199 P39052
    Dynamin 3 Human DNM3 NM_015569 Q9NQ68
    Mouse Dnm3 NM_001038619 Q8BZ98
    Rat Dnm3 NM_138538 Q08877