Vinblastine sulfate

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Cat.No. 1256 - Vinblastine sulfate | C46H58N4O9.H2SO4 | CAS No. 143-67-9
Description: Disrupts microtubules
Chemical Name: Vincaleukoblastine
Purity: ≥95% (HPLC)
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.

Technical Data

M. Wt 909.06
Formula C46H58N4O9.H2SO4
Storage Desiccate at +4°C
Purity ≥95% (HPLC)
CAS Number 143-67-9
PubChem ID 241902
InChI Key KDQAABAKXDWYSZ-JKDPCDLQSA-N
Smiles OS(O)(=O)=O.[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 90.91 100
DMSO 90.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 909.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.1 mL 5.5 mL 11 mL
5 mM 0.22 mL 1.1 mL 2.2 mL
10 mM 0.11 mL 0.55 mL 1.1 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741 PMID: 3986806

Rai and Wolf (1998) Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 273 31131 PMID: 9813016

Tsukidate et al (1993) Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 143 918 PMID: 8362985

Veldhoen et al (2012) The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 32 736 PMID: 22430212


If you know of a relevant reference for Vinblastine sulfate, please let us know.

Keywords: Vinblastine sulfate, Vinblastine sulfate supplier, Disrupts, microtubules, Mitosis, Tau, Tubulin, chemotherapeutics, Microtubules, Autophagy, 1256, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Vinblastine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

5 Citations for Vinblastine sulfate

Citations are publications that use Tocris products. Selected citations for Vinblastine sulfate include:

Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007

Musiwaro et al (2013) Characteristics and requirements of basal autophagy in HEK 293 cells. BMC Cancer 9 1407 PMID: 23800949

Kathawala et al (2014) Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study. Mol Cancer Ther 13 714 PMID: 24431074

Ahmad et al (2010) Catharanthus roseus Aqueous Extract is Cytotoxic to Jurkat Leukaemic T-cells but Induces the Proliferation of Normal Peripheral Blood Mononuclear Cells. Trop Life Sci Res 21 101 PMID: 24575203

Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202


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