Vinblastine sulfate

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Description: Disrupts microtubules
Chemical Name: Vincaleukoblastine
Purity: ≥95% (HPLC)
Datasheet
Citations (6)
Reviews (1)
Literature (3)

Biological Activity for Vinblastine sulfate

Vinblastine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.

Technical Data for Vinblastine sulfate

M. Wt 909.06
Formula C46H58N4O9.H2SO4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 143-67-9
PubChem ID 241902
InChI Key KDQAABAKXDWYSZ-JKDPCDLQSA-N
Smiles OS(O)(=O)=O.[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Vinblastine sulfate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 90.91 100
DMSO 90.91 100

Preparing Stock Solutions for Vinblastine sulfate

The following data is based on the product molecular weight 909.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.1 mL 5.5 mL 11 mL
5 mM 0.22 mL 1.1 mL 2.2 mL
10 mM 0.11 mL 0.55 mL 1.1 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets for Vinblastine sulfate

Certificate of Analysis / Product Datasheet
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References for Vinblastine sulfate

References are publications that support the biological activity of the product.

Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741 PMID: 3986806

Rai and Wolf (1998) Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 273 31131 PMID: 9813016

Tsukidate et al (1993) Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 143 918 PMID: 8362985

Veldhoen et al (2012) The chemotherapeutic agent PacT. inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 32 736 PMID: 22430212


If you know of a relevant reference for Vinblastine sulfate, please let us know.

Keywords: Vinblastine sulfate, Vinblastine sulfate supplier, Disrupts, microtubules, Mitosis, Tau, Tubulin, chemotherapeutics, Microtubules, Autophagy, 1256, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Vinblastine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

6 Citations for Vinblastine sulfate

Citations are publications that use Tocris products. Selected citations for Vinblastine sulfate include:

Kathawala et al (2014) Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study. Mol Cancer Ther 13 714 PMID: 24431074

Bernier et al (2019) Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia. Cell Rep 27 2895 PMID: 31167136

Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007

Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202


Do you know of a great paper that uses Vinblastine sulfate from Tocris? Please let us know.

Reviews for Vinblastine sulfate

Average Rating: 5 (Based on 1 Review.)

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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma.
By Anonymous on 11/17/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Human epidermal carcinoma cell line

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007
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Literature in this Area

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