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Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 909.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.1 mL||5.5 mL||11 mL|
|5 mM||0.22 mL||1.1 mL||2.2 mL|
|10 mM||0.11 mL||0.55 mL||1.1 mL|
|50 mM||0.02 mL||0.11 mL||0.22 mL|
References are publications that support the biological activity of the product.
Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741 PMID: 3986806
Rai and Wolf (1998) Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 273 31131 PMID: 9813016
Tsukidate et al (1993) Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 143 918 PMID: 8362985
Veldhoen et al (2012) The chemotherapeutic agent PacT. inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 32 736 PMID: 22430212
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Keywords: Vinblastine sulfate, Vinblastine sulfate supplier, Disrupts, microtubules, Mitosis, Tau, Tubulin, chemotherapeutics, Microtubules, Autophagy, 1256, Tocris Bioscience
6 Citations for Vinblastine sulfate
Citations are publications that use Tocris products. Selected citations for Vinblastine sulfate include:
Kathawala et al (2014) Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study. Mol Cancer Ther 13 714 PMID: 24431074
Ahmad et al (2010) Catharanthus roseus Aqueous Extract is Cytotoxic to Jurkat Leukaemic T-cells but Induces the Proliferation of Normal Peripheral Blood Mononuclear Cells. Trop Life Sci Res 21 101 PMID: 24575203
Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202
Bernier et al (2019) Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia. Cell Rep 27 2895 PMID: 31167136
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007
Musiwaro et al (2013) Characteristics and requirements of basal autophagy in HEK 293 cells. BMC Cancer 9 1407 PMID: 23800949
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Reviews for Vinblastine sulfate
Average Rating: 5 (Based on 1 Review.)
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Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
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