JNK/c-Jun

JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by various environmental stresses. They can also be activated by cytokines and growth factors.

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
2651 AEG 3482
Inhibitor of JNK signaling
3314 BI 78D3
Selective, competitive JNK inhibitor
1989 c-JUN peptide
Peptide inhibitor of JNK/c-Jun interaction
6258 CC 401 dihydrochloride
High affinity JNK inhibitor; also inhibits HCMV replication
4924 CEP 1347
Inhibitor of JNK signaling
5575 IQ 1S
JNK inhibitor; anti-inflammatory; also NO donor
4550 IQ 3
Selective JNK3 inhibitor
1565 JIP-1 (153-163)
JNK-selective inhibitor peptide
1496 SP 600125
Selective JNK inhibitor
5044 SR 3576
Highly potent and selective JNK3 inhibitor
3607 SU 3327
Selective JNK inhibitor
2827 TCS JNK 5a
Selective inhibitor of JNK2 and JNK3
3222 TCS JNK 6o
Selective JNK inhibitor

Activators

Cat No Product Name / Activity
1290 Anisomycin
JNK, SAPK and p38 activator

JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by a variety of environmental stresses. They are also activated in response to cytokines such as TNF-α and IL-1, and growth factors.

There are three isoforms of JNK; JNK1, JNK2 and JNK3. JNK1 and JNK2 are ubiquitously expressed, whilst JNK3 expression is limited to the brain, heart and testis. JNK phosphorylates a wide variety of substrates including c-Jun. c-Jun is a component of the AP-1 transcription factor complex and is involved in the control cell proliferation, transformation, survival and death. JNK also phosphorylates p53 and some non-nuclear proteins. JNK-mediated phosphorylation of target proteins is essential for the induction of gene expression of interleukins, VEGF, COX-2, MMP-9, heme oxygenase-1, ICAM-1, NCX1, GnRHR and others.

JNK is critical in processes as divergent as apoptosis, cell survival, proliferation and differentiation. The JNK pathway appears to be involved in inflammatory and autoimmune disorders including rheumatoid arthritis, irritable bowel disease, and atherosclerosis.

Literature for JNK/c-Jun

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for JNK/c-Jun

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

JNK/c-Jun Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
JNK1 Human MAPK8 NM_139047 P45983
Mouse Mapk8 NM_016700 Q91Y86
Rat Mapk8 XM_341399 P49185
JNK2 Human MAPK9 NM_139069 P45984
Mouse Mapk9 NM_016961 Q9WTU6
Rat Mapk9 NM_017322 P49186
JNK3 Human MAPK10 NM_002753 P53779
Mouse Mapk10 NM_009158 Q61831
Rat Mapk10 NM_012806 P49187
c-Jun Human JUN NM_002228 P05412
Mouse Jun NM_010591 P05627
Rat Jun NM_021835 P17325