AP-1

Activator Protein-1 (AP-1) is a collective term referring to dimeric transcription factors composed of Jun, Fos, Jun-dimerization partners or ATF subunits. They bind to AP-1 DNA recognition elements known as TREs and control cell proliferation, transformation, survival and death.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
1989 c-JUN peptide
JNK/c-Jun interaction inhibitor
5309 SP 100030
NF-κB and AP-1 dual inhibitor
2476 SR 11302
AP-1 inhibitor; antitumor agent

Activator Protein-1 (AP-1) is a collective term referring to dimeric transcription factors composed of Jun (v-Jun, c-Jun, JunB, JunD), Fos (v-Fos, c-Fos, FosB, Fra1, Fra2), Jun-dimerization partners (JDP1, JDP2) or ATF (ATF2, ATF3, B-ATF) subunits. They bind to AP-1 DNA recognition elements known as TREs (phorbol 12-O-tetradecanoate-13-acetate response elements) and control cell proliferation, transformation, survival and death.

AP-1 complexes are regulated by controling expression of the subunit genes and by modulating their stability. This is achieved through phosphorylation, mediated by ERK, JNK and p38 MAP kinases. The glucocorticoid receptor is an important inhibitor of AP-1 activity, and other inhibitors include JAB1 and interferon-inducible p202. Differential expression of AP-1 subunit proteins in response to extracellular stimuli, such as growth factors, oncoproteins, cytokines and shortwave length UV irradiation, explains why these transcription factors have such diverse biological actions. For example, pro-mitogenic AP-1 complexes, especially those containing c-Jun, accomplish their growth promoting functions through repression of tumor suppressor genes such as p53, p21cip1/waf1 and p16. In contrast, JunB-containing AP-1 complexes mediate growth inhibitory and apoptotic functions by upregulating tumor suppressor genes and repressing cyclin D1.

It is very problematic to assign a specific and well-defined biological role to AP-1, as a large array of responses are regulated by this heterogeneous transcription factor. AP-1 contributes to cell growth, proliferation, malignant transformation and, under extreme conditons, activation of the apoptotic cascade.

Literature for AP-1

Cancer

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A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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A collection of over 190 products for immunology research, the guide includes research tools for the study of:

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AP-1 Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
c-Jun Human JUN NM_002228 P05412
Mouse Jun NM_010591 P05627
Rat Jun NM_021835 P17325
JunB Human JUNB NM_002229 P17275
Mouse Junb NM_008416 P09450
Rat Junb NM_021836 P24898
JunD Human JUND NM_005354 P17535
Mouse Jund NM_010592 P15066
Rat Jund NM_138875 P52909
c-Fos Human FOS NM_005252 P01100
Mouse Fos NM_010234 P01101
Rat Fos NM_022197 P12841
FosB Human FOSB NM_006732 P53539
Mouse Fosb NM_008036 P13346
Rat Fosb NM_001013146 Q62738
Fra1 Human FOSL1 NM_005438 P15407
Mouse Fosl1 NM_010235 P48755
Rat Fosl1 NM_012953 P10158
Fra2 Human FOSL2 NM_005253 P15408
Mouse Fosl2 NM_008037 P47930
Rat Fosl2 NM_012954 P51145
JDP1 Human BATF3 NM_018664 Q9NR55
Mouse Batf3 NM_030060 Q9D275
Rat Batf3 NM_021865 P97876
JDP2 Human JDP2 NM_130469 Q8WYK2
Mouse Jdp2 NM_030887 P97875
Rat Jdp2 NM_053894 Q78E65
ATF2 Human ATF2 NM_001880 P15336
Mouse Atf2 NM_001025093 P16951
Rat Atf2 NM_031018 Q00969
ATF3 Human ATF3 NM_001674 P18847
Mouse Atf3 NM_007498 Q60765
Rat Atf3 NM_012912 P29596
B-ATF Human BATF NM_006399 Q16520
Mouse Batf NM_016767 O35284
Rat Batf NM_001106748 XP_216745